Clinically healthy adult black Bengal female goats were used to investigate the pharmacokinetics of closantel following intravenous administration (10 mg/kg) both in healthy and in liver damaged goats. Induction of liver damage was done by subcutaneous injection of carbontetrachloride at 0.75 mL/kg on three occasion at 48 h interval. After administration of drug, blood samples were collected in...

Background: Orbifloxacin is being widely used in China to treat fish infections in an extra-label manner, which may cause its potential residues in edible tissues. Aims: The purpose of this study was to determine the disposition kinetics of orbifloxacin in crucian carp (Carassius auratus) following intramuscular administration for its further safe appl...

Letters to the Editor Letter from Dr. D.S. Sitar Sir: The study of drug disposition and effect as a function of the aging process is an increasingly important area of investigation. Cuny et al. (1) have recently reported results of their study concerning the effect of aging on salicylate disposition in this journal. Upon review of their publication, important deficiencies were noted which requi...

introduction: critical thinking as a process of purposeful self-regulatory judgment leads to problem solving and correct decision making in individuals. in the modern world, health care faces rapid change and burgeoning amount of knowledge. possessing critical thinking is essential for individuals in health care centers, specially when they are forced to solve clinical problems. the aim of this...

Paracetamol (Acetaminophen), a NSAID is well tolerated and lacks many side effects of aspirin. It is a widely used over-the-counter analgesic, antipyretic and weak anti-in ammatory property. The main mechanism is the inhibition of cyclooxygenase (COX) and recent  ndings suggest that it is highly selective for COX-2 (Henz et al., 2008). The present study was aimed to study the disposition kine...