Antecedentes: La Neuromielitis Óptica, también llamada enfermedad de Devic, es una entidad autoinmune desmielinizante del Sistema Nervioso Central, poco común que compromete los nervios ópticos y la médula espinal, ocasionando pérdida agudeza visual afección motora. Descripción caso: se presenta el caso clínico mujer 25 años, signos mielopatía amaurosis súbitas, cumpliendo criterios para neurom...

W hat is the most important moment in the history of a disease? Let us consider neuromyelitis optica (NMO), which was coined by French neurologist Eugene Devic in 1894 for a disease believed until recently to be a subtype of multiple sclerosis (MS). The discovery (in 2004) of a disease-specific biomarker for NMO revolutionized our understanding of both NMO and MS (1). In PNAS, Hinson et al. (2)...

Résumé La neuromyélite optique de Devic est une pathologie inflammatoire démyélinisante du système nerveux central qui affecte électivement la moelle spinale, le nerf optique et les régions cérébrales à haute expression d’antigènes aquaporine 4. Il s’agit d’une pathologie auto-immune sévère due à des auto-anticorps dirigés contre l’aquaporine 4, à taux de morbidité et de mortalité élevé. Contra...

of illnesses with varied etiology. They range from clearly infectious diseases such as progressive multifocal leucoencephalopathy to hereditary metabolic disorders such as adrenoleucodystrophy and metachromatic leucodystrophy to a group of disorders of unknown etiology (Table 14.1). Whether multiple sclerosis (MS) and its variants comprise a single disease with a highly varied course or a group...