HUMAN beings with hyperadrenocorticism (e.g. Cushing's syndrome) frequently develop premature, severe atherosclerosis.7' 8 This fact assumes new importance at the present time, when chronic hyperadrenocortical states are being artificially induced on a large scale for therapeutic purposes. The widespread utilization of corticotropin (ACTH) and adrenal steroids in clinical medicine compels a tho...

Technical Papers The Immediate Pressor Effect of Desoxycorticosterone Acetate: Melvin L. Goldman and Henry A. Schroeder ... 272 The Nasal Cavity of the Rat in Pharmacological and Other Experimentation: George Kelemen 273 Sorption of Fumigant Vapors by Soil: Irvin Fuhr, Aurora V. Bransford, and Seymour D. Silver ........... ..................... 274 Staining of the Stem Tissue of Plants by Triph...

ion of solutes without water in the distal tubule, and if sodium salt cannot be reabsorbed at this site in adrenal insufficiency, it should be impossible to excrete a really dilute urine even in the total absence of ADH in this disorder. The site of action of aldosterone is not known and this is an important area for research.'8"' Studies with desoxycorticosterone glucoside and cortisone sugges...

It has been widely accepted that intramuscular administration of synthetic 11-desoxycorticosterone acetate (DOCA) causes urinary retention of sodium, chloride and water, and loss of potassium both in normal subjects and in those with adrenocortical insufficiency."'8"' There is, however, a paucity of published information concerning many aspects of this question which have an important bearing o...

HUMAN beings with hyperadrenocorticism (e.g. Cushing's syndrome) frequently develop premature, severe atherosclerosis.7' 8 This fact assumes new importance at the present time, when chronic hyperadrenocortical states are being artificially induced on a large scale for therapeutic purposes. The widespread utilization of corticotropin (ACTH) and adrenal steroids in clinical medicine compels a tho...