Single electron transfer (SET)-photochemical decarboxylation of free carboxylic acids was performed in a polar solvent using several arenes such as phenanthrene, naphthalene, 1-methylnaphthalene, biphenyl, triphenylene, and chrysene in the presence of various electron acceptors such as 1,2-, 1,3-, and 1,4-dicyanobenzenes, methyl 4-cyanobenzoate, and 1,4-dicyanonaphthalene. The decarboxylation r...

Decarboxylative coupling reactions offer an attractive route to generate functionalized arenes from simple and readily available carboxylic acid coupling partners, yet they are underutilized due to limitations in the scope of carboxylic acid coupling partner. Here we report that the field effect parameter (F) has a substantial influence on the rate of decarboxylation of well-defined silver benz...

In connection with studies on the /3-keto acid carboxylases of plants (1, 2), the effects of metal ions on the decarboxylation of oxalacetic acid, in the presence and absence of enzyme, were studied. In confirmation of Krebs (3) the decarboxylation was found to be accelerated by a variety of polyvalent cations. It was also observed that the enzyme oxalacetic carboxylase from parsley roots, whic...

Malic dehydrogenase has been shown to catalyze the reduction of diketosuccinate by DPNH (4). Furthermore, both oxaloglycolate and diketosuccinate undergo spontaneous decarboxylation in aqueous solution. These nonenzymatic reactions complicate the analysis of the metabolic path of degradation of tartrate. As a prerequisite for the use of labeled compounds to study the biochemical synthesis and d...

The isomeric composition of type-III heptacarboxylic porphyrinogens derived from decarboxylation of uroporphyrinogen III by erythrocyte uroporphyringogen decarboxylase was analysed by h.p.l.c. with electrochemical detection. All four possible isomers were identified, and there were little differences in the proportion of isomers formed by erythrocytes from normal subjects and from patients with...

Hepta-, hexa-, and pentacarboxylic porphyrins have been detected in porphyric as well as normal urine samples. From the former they have been isolated and converted into pure methyl esters (1). For a better understanding of the chemistry of these porphyrins, pure uroporphyrin I and uroporphyrin III were separately subjected to decarboxylation under controlled conditions. The decarboxylation pro...

We describe the palladium-catalyzed multicomponent synthesis of 2-imidazolines. This reaction proceeds via the coupling of imines, acid chlorides and carbon monoxide to form imidazolinium carboxylates, followed by a decarboxylation. Decarboxylation in CHCl(3) is found to result in a mixture of imidazolinium and imidazolium salts. However, the addition of benzoic acid suppresses aromatization, a...