The development of noninvasive approaches to facilitate the regeneration of post-traumatic nerve injury is important for clinical rehabilitation. In this study, we investigated the effective dose of noninvasive 808-nm low-level laser therapy (LLLT) on sciatic nerve crush rat injury model. Thirty-six male Sprague Dawley rats were divided into 6 experimental groups: a normal group with or without...

BACKGROUND Walking track analysis which has been widely used to examine the recovery of gait functions in rats with sciatic nerve injury. PURPOSE The present study was aimed to objectively analyze and quantify the degree of functional recovery in locomotor behavior of rats after inflicting sciatic nerve crush injury. METHODS Wistar rats trained on various runways, viz., narrow beam, grid an...

The influence of direct electric stimulation on nerve regeneration was studied in a model of crush injury of the sciatic nerve of rats. Forty-three rats were used and distributed in four groups according to the procedure: (1) intact nerve, inactive circuit; (2) crush injury, inactive circuit; (3) intact nerve, active circuit; (4) crush injury, active circuit. The low intensity continuous curren...

BACKGROUND The term acute kidney injury (AKI) and its classification in strata defined as Risk, Injury, Failure, Loss and End-stage renal failure (RIFLE) need to be validated in different patient groups. RIFLE may be useful to foresee medical and logistic problems in crush-related AKI in disaster victims. METHODS Taken from the Marmara earthquake crush database, the subjects included 416 pati...

Purpose Enhanced regeneration of retinal ganglion cell (RGC) axons can be achieved by modification of numerous neuronal-intrinsic factors. However, axon growth initiation and the pathfinding behavior of these axons after traumatic injury remain poorly understood outside of acute injury paradigms, despite the clinical relevance of more chronic settings. We therefore examined RGC axon regeneratio...

life in the modern world means existing with the evolving face of modern warfare and global terrorism. we have disasters both man-made disasters, natural. man has devised weapons of mass destruction, which in the hands urban terrorists can cause blasts, building collapses. resulting in a unique pattern of damage to the human body namely, crush injuries “crush syndrome” first recorded in bombing...

Morphological methods were used to examine injury-induced growth of peripheral and central axons of nociceptive mechanosensory neurones in the ventrocaudal (VC) clusters of the pleural ganglia of Aplysia californica. Pedal nerve crush transected all axons in the nerve while leaving the overlying sheath largely intact. Immunohistochemical staining was performed with an antibody to a sensory-neur...

BACKGROUND Crush trauma to the extremities, even if not involving vital organs, can be life threatening. Crush syndrome, the systemic manifestation of the breakdown of muscle cells with release of contents into the circulation, leads to metabolic derangement and acute kidney injury. Although common in disaster scenarios, emergency physicians also see the syndrome in patients after motor-vehicle...

Sciatic nerve axons in cyclin D1 knockout mice develop normally, become properly ensheathed by Schwann cells, and appear to function normally. However, in the Wallerian degeneration model of nerve injury, the mitotic response of Schwann cells is completely inhibited. The mitotic block is Schwann cell autonomous and developmentally regulated. Rescue analysis (by "knockin" of cyclin E) indicates ...