* Corresponding Author Email: [email protected] One of the common chronic inflammatory skin diseases is Acne Vulgaris that affects up to 80% of a teen-age population. The progress of acne lesions is due to colonization of Propionibacterium acnes (P .acnes) in hair follicles. Treatment of acne includes topical or systemic therapy or combination therapy, with a tendency to perform topical therapy...

The objective of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of the poorly water-soluble compound 20(S)-25-methoxydammarane-3β;12β;20-triol (25-OCH3-PPD). Optimized SMEDDS formulations for 25-OCH3-PPD contained Cremophor® EL (50%) as the surfactant, glycerin (20%) as the cosurfactant, and Labrafil® M1944 (30%) as the oil. T...

The purpose of the present study was to investigate the effect of nanoemulsions as a carrier vehicle of hydrophilic drug for transdermal delivery. The response surface methodology with a mixture design was used to evaluate the effect of ingredient levels of nanoemulsion formulations including cosurfactant (isopropyl alcohol, 20 ∼ 30%), surfactant (mixed of Brij 30 and Brij 35, 20 ∼ 30%), and di...

Complexes of double-stranded DNA with the cationic surfactant cetyltrimethylammonium bromide have been studied using small angle x-ray diffraction at varying concentrations of DNA and the cosurfactant hexanol. At low DNA concentrations, an intercalated hexagonal (H(c)(I))-->lamellar (L(c)(alpha))-->inverted hexagonal (H(c)(II)) transformation is found on increasing hexanol content. The H(c)(II)...

In the present work, levofloxacin based microemulsion was developed and its usefulness as topical drug carrier system for anti bacterial activity was investigated. Microemulsion was prepared by phase titration method using oleic acid as oil phase, tween-60 as surfactant and isopropyl alcohol as co-surfactant. Five different formulations were formulated with various amount of the oil, water and ...

X-ray scattering studies were performed to understand the structure and correlations in the lamellar phases of thick, freely suspeded films of (i) the hydrated phospholipid dimyristoylphosphotidylcholine (DMPC) and (ii) the ternar system consisting of the surfactant sodium dodecyl sulfate (SDS), cosurfactant (pentanol), and water. The films were drawn in a temperature- and humidity-controlled e...

Despite their lack of thermodynamical stability, nanoemulsions can show a remarkable degree of kinetic stability. Among the various different preparation methods the phase-inversion concentration method is particularly interesting as it occurs spontaneously. Here we investigate such a system composed of a surfactant, cosurfactant, and oil that upon dilution with water forms long time metastable...

The novel carriers have been exploited through almost all the routes of administration. Association of drugs with carriers is normally noncovalent, based on collective strength of weak binding forces. Many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfa...