Berry, L. Joe (Bryn Mawr College, Bryn Mawr, Pa.), Dorothy S. Smythe, and Louise S. Colwell. Inhibition of inducible liver enzymes by endotoxin and actinomycin D. J. Bacteriol. 92:107-115. 1966.-Bacterial endotoxin at the ld(50) level lowers liver tryptophan pyrrolase in mice, it prevents for 16 to 20 hr the induction of the enzyme by a concurrent injection of cortisone, it lowers significantly...

Intra-articular hydrocortisone therapy has been in extensive use for approximately 5 years. It has been stated that this therapy is strictly for local palliation and has no systemic effects (Hollander, 1953). Local hydrocortisone therapy is especially recommended in cases in which the systemic use of cortisone is contra-indicated on general medical grounds (Kersley, 1953). On the other hand, Yo...

DISILLUSIONMENT and disappointment frequently follow the initial enthusiasm for using a new therapeutic substance. Only prolonged and careful study by many workers reveals the true value and the limitations of a new drug. When Hench and his associates at the Mayo Clinic introduced cortisone for the systemic treatment of rheumatoid arthritis (Hench et. al., 1949) hopes ran high at first, but gra...

A study was made of the pathogenesis of infection due to the Conn.-5 strain of Coxsackie virus in 4 to 5 day old infant mice, untreated adult mice, and adult mice treated with cortisone. The quantitative distribution of virus and the evolution of lesions in different tissues were followed for the first 7 days of the infection. Virus dissemination was prompt and widespread via the blood in all g...

Adult female (NZB + NZW)F1 mice were treated with cortisone, cortisone with tolerogen (isologous NZB IgG-nucleosides conjugates) or cortisone with isologous IgG free of nucleosides. Other treatments also included tolerogen or isologous IgG alone, and cortisone together with denatured DNA. All untreated mice died by 10 mo of age. Cortisone prolonged the survival rate. This effect was further imp...

A substance has been demonstrated in solutions of crude papain, which, when injected intravenously into 1 kilo rabbits, in amounts less than 5 mg., results in complete collapse of both ears. The phenomenon becomes visible 4 hours after injection, and is complete within 24 hours. 3 or 4 days after papain, the ears gradually reassume their normal form. Ear collapse is associated with depletion of...

Tarsal coalitions are a group of osseous anomalies where there is bridge between two or more bones that normally does not exist. This often results in decreased abnormal motion which can lead to pain and deformity over time. case report centers on 41-year-old male with rare coalition the lateral cuneiform cuboid foot was identified magnetic resonance imaging (MRI) after plain radiographs failed...

INTRODUCTION This case report presents for the first time an acute systemic allergic reaction to corticosteroids in a patient with ocular toxoplasmosis after treatment with intravenous cortisone, and discusses alternative treatments. CASE PRESENTATION We present the case of a 57-year-old Caucasian woman with an anaphylactic reaction after intravenous injection of prednisolone-21-hydrogensucci...

The administration of glucocorticoids may decrease intestinal calcium absorption in vivo and the active transport of calcium in rat duodenum in vitro. It has been suggested that this apparent "anti-vitamin D-like" effect of steroid hormones may be related to alterations in vitamin D metabolism. In order to test this hypothesis, vitamin D-deficient control and cortisone-treated rats were given a...

OBJECTIVE To describe the pain and functional improvements of a patient with posterior ankle impingement following a treatment plan incorporating soft tissue therapy, chiropractic adjustment and a progressive rehabilitation program. CLINICAL FEATURES A 37-year- old male presented with posterolateral ankle pain exacerbated by plantar flexion two weeks after sustaining an inversion ankle sprain...