______________________________________________________________________________ In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The e...

For detection of cardiac ischemia based on regional pCO2 measurement, sensor drift becomes a problem when monitoring over several hours. A real-time drift correction algorithm was developed based on utilization of the time-derivative to distinguish between physiological responses and the drift, customized by measurements from a myocardial infarction porcine model (6 pigs, 23 sensors). IscAlertT...

Two simple, rapid and accurate conductometric methods were developed for determination of losartan potassium, pantoprazole sodium, sumatriptan succinate, rabeprazole sodium and lomefloxacine HCl in pure form as well as in their pharmaceutical formulations. The proposed methods based on using two different precipitating agents for conductometric determination of the cited drugs. Method (A) based...

A conductometric biosensor using immobilised Chlorella vulgaris microalgae as bioreceptors was used as a bi-enzymatic biosensor. Algae were immobilised inside bovine serum albumin membranes reticulated with glutaraldehyde vapours deposited on interdigitated conductometric electrodes. Local conductivity variations caused by algae alkaline phosphatase and acetylcholinesterase activities could be ...

Johne's disease (JD) is one of the most costly bacterial diseases in cattle. In the U.S., economic losses from the disease have been estimated to exceed $1,500,000,000 per year, mainly from the effects of reduced milk production. Current diagnostic tests for JD are laboratory based and many of those tests require specialized equipment and training. Development of rapid and inexpensive diagnosti...

A novel biosensor based on immobilised whole cell Chlorella vulgaris microalgae as a bioreceptor and interdigitated conductometric electrodes as a transducer has been developed and tested for alkaline phosphatase activity (APA) analysis. These sensors were also used for the detection of toxic compounds, namely cadmium ions, in aquatic habitats. Algae were immobilised inside bovine serum albumin...

The solution properties of some cationic polyelectrolytes with ammonium quaternary centers either attached to an acrylic macromolecular chain (polycation PDMAEMQ type) or in the backbone (polycation PCA type) have been measured in order to identify how charge density, polyelectrolyte concentration, solvent polarity as well as temperature influence their behavior in solution by viscometric, cond...