Neoplasms of the central nervous system (CNS) are a pathologically diverse group of benign and malignant tumors for which a variety of management strategies, including observation, surgery, radiation therapy, and/or chemotherapy, are employed. Shown in Table 1 are the usual radiation doses used to treat primary and metastatic brain and spinal cord tumors, which span a broad range of total doses...

background: in this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to mahak pediatric cancer treatment and research center (one of the main national referral centers for childhood malignancies in iran) for treatment. materials and methods: this cohort (simple sampling) study consisted of 198 children less than 15 year old with cns tumor refer...

PURPOSE To evaluate the effect of rituximab monoclonal antibody (mAb) on MRI tumor volumetrics and efficacy in a rat model of central nervous system (CNS) lymphoma when delivery to the brain was optimized with osmotic blood-brain barrier disruption (BBBD). EXPERIMENTAL DESIGN Female nude rats with intracerebral MC116 human B-cell lymphoma xenografts underwent baseline MRI and were randomized ...

Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that potently and selectively inhibits EGFR TKI-sensitizing T790M resistance mutations with demonstrated efficacy in EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC), including central nervous system (CNS) metastases. the preferred first-line treatment EGFRm advance...

Most primary CNS tumors are astrocytic tumors. Glial classified according to histological criteria. The WHO classification for malignant gliomas in adults includes grades II through IV. Terms that classify grade astrocytomas (A), oligodendrogliomas (ODG), or mixed (GM). Grade III named similarly, and preceded by the word anaplastic, example, anaplastic astrocytoma (AA), oligodendroglioma (ODGA)...

Abstract Glioblastomas are known to be highly therapy resistant tumors. The description of tumor microtubes (TMs) as long cellular protrusions that connect glioblastoma cells a network against all standard therapies advanced the basic biological understanding disease and offers new therapeutic target. An antisense oligonucleotide (ASO) production protein involved in formation function TMs was d...

Abstract Background Cavitating ultrasonic aspirator (CUSA) devices are commonly used in neurosurgical procedures to carefully debulk tumor from adjacent healthy brain tissue. Here, we explore the feasibility of using minced tissue classify otherwise discarded sample material by DNA methylation according respective World Health Organization (WHO) Classification Tumors Central Nervous System (CNS...

1985 marked the first reporting of a specific gene alteration in a human central nervous system (CNS) tumor: epidermal growth factor receptor (EGFR) gene amplification in glioblastoma (43). Since that time, a relatively short period by most standards, neuro-oncology research has revealed many genetic abnormalities that indicate consistent genotype-phenotype associations for the various cancers ...