Background: Currently clomiphene citrate is the first-line treatment to induce ovulation in women with polycystic ovarian syndrome (PCOS). Surgical therapy with laparoscopic ovarian drilling (LOD) may avoid or reduce the need for gonadotropins. Objective: To determine the effectiveness and safety of LOD compared with ovulation induction in subfertile women with clomiphene-resistant PCOS. Search...

(2006) and Sahin et al. (2004) is not correct. Khorram et al. randomized patients between metformin plus clomiphene and clomiphene alone. Metformin was started in the same cycle as was clomiphene. Sahin et al. did treat the patients with metformin 3 months prior to administrating clomiphene, but all patients also received clomiphene, which also makes the comparison justifiable. Both these studi...

BACKGROUND Obese women with the polycystic ovary syndrome are relatively unresponsive to the induction of ovulation by clomiphene. We hypothesized that reducing insulin secretion by administering metformin would increase the ovulatory response to clomiphene. METHODS We performed oral glucose-tolerance tests before and after the administration of 500 mg of metformin or placebo three times dail...