1. When clofibrate [ethyl 2-(4-chlorophenoxy)-2-methylpropionate] was administered subcutaneously to rats (600mg/kg per day for 5 days), the concentration of CoA and its acyl derivatives increased in several tissues. The increase in total CoA was 3.2-fold in the liver, 1.8-fold in the kidney, 2.7-fold in the heart and 2.4-fold in skeletal muscle. 2. To study the mechanism of this phenomenon, cl...

Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated regarding the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis in primary cultures of rat hepatocytes. Low toxicity concentrations, 200 and 100 microg/ml for phenobarbital and clofibrate respectively, were used to examine their effect on spontaneous or transforming growth...

Breast cancer resistance protein (Bcrp/Abcg2) localized at the blood-brain barrier (BBB) limits permeability into the brain of many xenobiotics, including pharmacological agents. Peroxisome proliferator-activated receptor α (Pparα), a ligand-activated transcription factor, primarily involved in lipid metabolism, has been shown to regulate the functional expression of Bcrp in human cerebral micr...

background: neonatal jaundice is a common problem that can result in serious neurological side effect such as kern icterus. several drugs are used to prevent neonatal jaundice. the effect of clofibrate in the prevention of hyperbilirubi-nemia in healthy term neonates has not been paid attention to. this study aimed to evaluate the preventive effect of clofibrate on neonatal jaundice in term neo...

OBJECTIVE To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. METHODS A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines from the Cochrane review group and the PRISMA statemen...

In chick embryo hepatocytes, triiodothyronine (T3) causes a 30- to 40-fold increase in malic enzyme activity when added between 1 and 3 days, but has no effect when added between 5 and 7 days in culture. This transcription-mediated decline in T3 responsiveness is partially reversed by corticosterone (Roncero, C. and A. G. Goodridge, 1992. Arch. Biochem. Biophys. 295: 258-267). Clofibrate also r...

BACKGROUND Utilization of energy-dense lipid fuels is critical to the rapid development and growth of neonates. OBJECTIVE To increase efficiency of milk fat utilization by newborn pigs, the effect of clofibrate on in vivo and in vitro long-chain fatty acid (LCFA) oxidation was evaluated. METHODS Newborn male pigs were administered 5 mL of vehicle (2% Tween 80) with or without clofibrate (75...

Clofibrate and an alternative hypolipidaemic drug, tiadenol, cause hepatomegaly with marked proliferation of peroxisomes and mitochondria (Hess et al., 1965; Kurup et a/., 1970; Roze et al., 1977). Subcellular fractionation studies have shown that the palmitoyl-CoA hydrolase activity is present both in the microsomal and mitochondrial fractions (Berge & Farstad, 1979; Berge & Dassland, 1979). A...