Recent work has shown the potential importance of IL-9 in allergic diseases. The development of transgenic mice overexpressing IL-9 has suggested a key role for this cytokine in the development of the asthmatic phenotype including airway eosinophilia. In this study, we evaluated the expression of the IL-9R and the effects of IL-9 on human ASM cells by examining the release of Th2-associated che...

The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero, but little is known about allergen-induced placental cytokine and chemokine release. The release of several cytokines and ...

Recently, many possible roles of non-thermal plasma (NTP) has been reported, representing the plasma as a novel tool in the field of dermatology. Unlike other light-based devices, multi-functional elements within the plasma including UVs, ions, reactive oxygen species drives many biological effect of the plasma, such as blood coagulation stimulation, anti-cancer activity and powerful killing ef...

Atopic dermatitis/AD patients have systemic biomarker dysregulation that differs by age group, but proteomic characteristics of these age-based changes are unknown. To profile blood proteins AD across different groups versus age-appropriate controls. Using the OLINK high-throughput platform, we profiled 375 serum 20 infants (0-5y/o), 39 children (6-11y/o), 21 adolescents (12-17y/o), and adults ...

Background Identification of patients with lymphocytic variant hypereosinophilic syndrome (L-HES) is challenging, and has important prognostic therapeutic implications. Objective This study was undertaken to assess diagnostic tools for L-HES develop evidence-based recommendations. Methods Biomarkers T-cell–driven disease were compared between versus idiopathic HES (I-...