Salomonsson, Max, and William J. Arendshorst. Calcium recruitment in renal vasculature: NE effects on blood flow and cytosolic calcium concentration. Am. J. Physiol. 276 (Renal Physiol. 45): F700–F710, 1999.—This study provides new information about the relative importance of Ca21 mobilization and entry in the renal vascular response to adrenoceptor activation. We measured renal blood flow (RBF...

CD40 is a member of the TNF receptor family that was initially described on the surface of B cells. Recently, CD40 has also been described on mesenchymal cells, such as endothelial cells and fibroblasts, where engagement by its ligand CD40 ligand can lead to up-regulation of costimulatory and cell adhesion molecules, as well as secretion of proinflammatory cytokines. Since airway inflammation p...

Seven patients suffering from hyperthyroidism have been carefully studied. An analysis of their experimental data provides definite evidence in favour of an associated hyperparathyroidism being the direct cause of the excessive mobilization and excretion of calcium and phosphorus. Two patients suffering from hyperthyroidism with an associated hypoparathyroidism were studied. Both patients were ...

CD19 (B4) is a signal transduction molecule restricted to the B-cell lineage and the target of the immunotoxin anti-B4-blocked ricin (anti-B4-bR), which is composed of the monoclonal antibody (MoAb) anti-B4 and the modified plant toxin blocked ricin. To explore the influence of conjugation of blocked ricin to anti-B4 on functional activation of CD19, we investigated the effects of anti-B4-bR, a...

PURPOSE sigma-1 Receptor ligands prevent neuronal death associated with glutamate excitotoxicity both in vitro and in vivo. However, the molecular mechanism of the neuroprotective effect remains to be elucidated. The present study was undertaken to determine whether sigma-1 receptor agonists provide neuroprotection by decreasing glutamate-induced calcium mobilization and preventing apoptotic ge...

The neuropeptide pituitary adenylate cyclase-activating protein (PACAP) acts via the G protein-coupled receptor vasoactive intestinal peptide/PACAP receptor-1 to induce phospholipase C/calcium and MAPK-dependent proinflammatory activities in human polymorphonuclear neutrophils (PMNs). In this study, we evaluate other mechanisms that regulate PACAP-evoked calcium transients, the nature of the ca...