1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)2D3 exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D recept...

BACKGROUND Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various ...

Abstract Background Behcet’s disease (BD) is a systemic inflammatory of the blood vessels and affects various body parts. This study aimed to determine association four single-nucleotide polymorphisms (SNPs) BD in Egyptian population using multiple statistical models show resulting associations along with previous studies different populations. Four SNPs were examined for their BD: two from vit...

Coronavirus infection a new infectious illness brought on by the SARS-COV-2 virus has infected people worldwide as of 2019, covid-19 disease is associated with hematological and biochemical parameters changes. The present study aimed to evaluate possible relationship between patient severity. A total 200 nasopharyngeal swabs whole blood specimens were collected from individuals suspected CoV-2 ...

BACKGROUND Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). VDR is a transcription factor modulating the expression of several genes in different pathways. Genetic variants in the VDR gene have been associated with several cancers in different population including colorectal cancer. OBJECTIVE To assess ...

We investigated the effect of vitamin D receptor gene (VDRG) polymorphism on the responsiveness to 1,25(OH)2D3 in human osteoblast-like cells. The cells were obtained from the femoral heads of 18 women with osteoarthritis of the hip. Three different restriction enzymes, BsmI, ApaI, and TaqI, were used to analyse the polymorphism. The genotypes of the 18 patients were bbAaTT (8), bbaaTT (6), BbA...

multiple sclerosis (ms) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. the main pathogenesis of ms has long been thought to be an immune mediated disorder of the central nervous system. the function of the immune system is under the influence of vitamin d which as a modulator of immune response could play a...

BACKGROUND Vitamin D deficiency and vitamin D receptor gene polymorphisms are known to be significantly associated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is largely unknown. This study investigated whether vitamin D receptor gene polymorphisms are altered in primary open-angle glaucoma subjects carrying the risk allele, and whether vitamin D defici...

Dental caries is a multifactorial disease with multiple risk factors. Vitamin D levels (VDLs) and vitamin receptor polymorphisms (VDRPs) have been investigated for this reason. The aim of narrative review to investigate the relation factors affecting deficiency (VDD), VDRP, Early Childhood Caries (ECC) Severe (S-ECC) in children (primary mixed dentition) dental adults (permanent dentition). Add...