Objective: To gain combined risk estimates for the BsmІ polymorphism in vitamin D receptor (VDR) gene associated with the risk of fractures in Caucasian population. Methods: We performed a meta-analysis and extracted 15 eligible publications by searching the databases of Medline, EMBASE and CNKI. Summary odds ratio (OR) with 95% confidence interval (CI) was estimated by using fixed-effects mode...

The polymorphisms of the vitamin D receptor (VDR) gene have been hypothesized to alter the risk of prostate cancer; however, published data concerning the association between VDR gene BsmI polymorphism and prostate cancer susceptibility are somewhat inconclusive. To evaluate the impact of VDR gene BsmI polymorphism on prostate cancer risk, a meta-analysis on all eligible studies including 7,666...

Aim: This study aimed to investigate the correlation between rates of coronavirus disease 2019 (COVID-19) prevalence and mortality frequency vitamin D receptor (VDR) gene polymorphisms at loci rs7975232 (ApaI), rs1544410 (BsmI), rs2228570 (FokI), rs731236 (TaqI) in cohorts from 26 countries.Methods: The included use countries where VDR (TaqI), (BsmI) were determined relevant frequencies alleles...

Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI is associated with bone mineral density (BMD) in Spanish postmenopausal women. A total of 210 unrelated healthy postmenopausal women aged 60 ± 8 years w...

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...

INTRODUCTION We studied the frequencies of the 3' and 5'-end vitamin D receptor (VDR) gene polymorphisms and their correlation with bone mineral density (BMD) in Egyptian pediatric acute lymphoblastic leukemia (ALL) patients receiving calcium and vitamin D supplements. The purpose of this study is to find out the relation between VDR polymorphism and the response to vitamin D intake in pediatri...

The aim of this study was to evaluate the possible association between polymorphisms in the Vitamin D receptor gene (VDR gene) and tendency for development of psoriasis vulgaris and diabetes mellitus in the population of Slavonia, which is a region in the Eastern Croatia. In order to conduct the mentioned evaluation the restriction fragment length polymorphisms (ApaI, BsmI and TaqI) in the Vita...

Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) are commonly studied in several pathologies. We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an Italian cohort of 266 patients with lumbar spine disorders assessed by Magnetic Resonance Imagin...