intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. however, soluble antigens (ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. so, in this study, tetanus toxoid ...

Over the past century, phytochemical and phyto pharmacological sciences established the compositions that are biological active and health promoting. Most of the biologically active constituents of plants are polar or water soluble molecules. However, water soluble phyto-constituents (like flavonoids, tannins, terpenoids, etc.) are poorly absorbed either due to their large molecular size which ...

Three most commonly used preparative methods, dry-film, reverse phase evaporation and ethanol injection were employed to prepare cationic liposomes composed of DC-Chol and DOPE, respectively. The resulting samples were contrasted through morphology observation, particle size and zeta potential analysis. Sephadex filtration method with high selectivity was developed to determine the encapsulatio...

BACKGROUND In the presence of ascorbic acid, degradation acylated (sinapic, ferulic and p-coumaric acid derivatives cyanidin-3-xylosylglucosylgalactoside) non-acylated anthocyanins black carrot extract (BCE) encapsulated in liposomes was studied. BCEs (0.2% 0.4% w/w) were using different lecithin concentrations (1%, 2% 4% w/w). RESULTS The prepared with particle diameters less than 50 nm zeta p...

Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...

The purpose of this study was to optimize a method for the encapsulation of P5 peptide, a new designed peptide containing MHC class I epitopes from rat HER2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. The efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

In the present study, effects of Origanum onites L. extract and essential oil O. on antioxidant status liver brain mice were investigated. Due to certain disadvantages oils, such as poor solubility, high volatility sensitivity UV light heat, formulation liposomes with Oregano essentials (OE) was optimized used in this study. The results demonstrated that best composition lipid carriers OE condu...

BACKGROUND Celecoxib is a selective cyclo-oxygenase-2 inhibitor recommended orally to treat arthritis and osteoarthritis. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40%. Long term oral administration of celecoxib causes serious gastrointestinal side effects. OBJECTIVES The current study aimed to assess the skin permeation of celecoxib by a transdermally...

PURPOSE The main objective of this study was to develop a novel aerosolized liposome formulation for pulmonary delivery of anti-asthmatic medication and to explore the relationship between the bioavailability and anti-asthmatic efficacy of such a formulation. Asthma treatment usually requires frequent administration of medication for sustained bronchodilating response. Liposomes are known for t...