Macrophage presence within atherosclerotic plaque is a feature of instability and a risk factor for plaque rupture and clinical events. Activated macrophages express high levels of the translocator protein/peripheral benzodiazepine receptor (TSPO/PBR). In this study, we investigated the potential for quantifying plaque inflammation by targeting this receptor. TSPO expression and distribution in...

According to the World Health Organization, cardiovascular diseases are the deadliest in the world, 17.1 million deaths per year are being caused by acute cardiovascular events (ACE) (ie, myocardial infarction and cerebral vascular accident). The lowand middleincome countries contribute to over 80% of cardiovascular disease deaths, which occur almost equally in men and women. In women, the car...

Stent under expansion is one of the reasons compromising outcomes percutaneous coronary interventions. The most common cause stent calcium deposited in atherosclerotic plaque. Adequate plaque modification paramount before placement a stent, as options to handle expanded are limited and less effective. In this case report, we explore usage knuckle wire for extrastent modification, after being fa...

BACKGROUND Unstable atherosclerotic plaque is a dangerous clinical state, possibly leading to acute coronary deficiency resulting in cardiac infarction. Inflammatory factor's role in creating pathological lesions in the endothelium of coronary vessels is frequently raised. This state may be caused by bacteria able to initiate clot formation in blood vessel and destabilizing atherosclerotic plaq...

OBJECTIVES Atherosclerosis is chronic inflammatory process triggered by oxidative stress. Oxidative stress can increase hydrogen peroxide (H2O2) level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (PVAT), foam cells, and atherosclerotic plaque. Antioxidant is needed to control negative effects of oxidative stress. One source of antioxidant,...

Atherosclerosis is a complex disease, the onset of which depends on various components of the vascular system, metabolism and immune system. It generates the fibro-fatty plaque or stable plaque characterized by accumulation of lipids in the intima of the arteries, a fibrous cap covering the atheromacore which may consists in lipid-laden cells (macrophages andvascular smooth muscle cells), prote...

BACKGROUND Type 2 diabetes and prediabetes are established risk factors for atherosclerosis. The aim of this study was to evaluate the atherosclerotic plaque burden in the carotid arteries of patients with acute coronary syndrome according to their glycemic status. METHODS Patients with acute coronary syndrome and no previous history of type 2 diabetes were consecutively included in the study...