Examination of antinuclear antibody (ANA) is used in diagnosis systemic autoimmune diseases, and the indirect immunofluorescence (IIF) assay using HEp-2 cells gold standard method. allows detection multiple target antigen-directed autoantibodies. The guide “The International Consensus on ANA Patterns (ICAP)”, characterizes patterns into three groups: nuclear, cytoplasmic, mitotic. majority thes...

month history of intermittent epistaxis. In addition, she reported a sensation of fullness and progressive hearing loss in her left ear over the previous two weeks. Our differential diagnosis for these unexplained symptoms of the upper airway focused on inflammatory diseases or a neoplasm involving the sinonasal tract and nasopharynx. Nasal endoscopy showed friable erythematous and granulomatou...

PURPOSE To describe an unusual case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome associated with a positive perinuclear antineutrophil cytoplasmic antibody test. METHODS This is an interventional case report. A 22-year-old man with decreased vision underwent ophthalmoscopic, angiographic, and laboratory evaluation. The left eye underwent laser therapy due to circin...

Granulomatosis with polyangiitis )GPA, also known as Wegener’s( is an anti-neutrophil cytoplasmic antibody-associatedmultisystem disease characterized by necrotizing small vessel vasculitis which mainly affects the upper and lower respiratorytracts well kidneys. Involvement of central nervous system uncommon in GPA might be difficult to treat.Pituitary involvement a rare presentation GPA. Prese...

<p>Drug-induced cutaneous vasculitis is a known autoimmune complication of tumor necrosis factor (TNF) inhibitors with many instances resulting in the production newly formed antibodies. We report 21-year-old female past medical history Crohn’s disease controlled infliximab who presented to dermatology purpuric rash and crusted plaques her distal lower extremities. Biopsy lesion revealed ...