Linear cationic antimicrobial peptides are a diverse class of molecules that interact with a wide range of cell membranes. Many of these peptides disrupt cell integrity by forming membrane-spanning pores that ultimately lead to their death. Despite these peptides high potency and ability to evade acquired bacterial drug resistance, there is a lack of knowledge on their selectivity and activity ...

Antibiotic resistance to pathogenic bacteria is becoming an increasing public health threat, and identifying alternatives antibiotics would be effective solution the problem of drug resistance. Antimicrobial peptides are small produced by various organisms; they considered adequate antibiotic substitutes because have intense, broad−spectrum antibacterial activity stability, widely available, ta...

Insects or products derived from insects are considered as a valuable feed ingredient for aquaculture, poultry, and pigs but also exert possible secondary effects of health stimulators in livestock reported literature. Health benefits attributed to can create additional value the insect chain. Three categories bioactive compounds this desk study: antimicrobial peptides (such ?-helical peptides,...

Antimicrobial peptides are short, positively charged, amphipathic peptides that possess a wide spectrum of antimicrobial activity and have an important role in the host's innate immunity. Lack of, or dysfunctions in, antimicrobial peptides have been correlated with infectious diseases, including periodontitis. Porphyromonas gingivalis, a gram-negative anaerobe and a major pathogen associated wi...

Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein gp41. With the emergence of drug resistance, there is an increased need for effective and unique alternatives within this class of antivirals. One...

Conventional antibiotics are facing significant microbial resistance, which has recently reached previously unnoticed critical levels. As a result of this situation, large proportion antimicrobial agents currently used in the clinic have significantly reduced therapeutic potential. Antimicrobial peptides (AMPs) may offer medical community an alternative strategy to traditional fight against res...

To prevent and treat diseases caused by the spread of microbes, humans have invented all sorts of effective antimicrobial substances. The most widely used antimicrobial substance is antibiotics. However, misuse of antibiotics can generate various negative effects, bacterial resistance, decreased immunity, and internal flora imbalance which can lead to endogenous infection. In addition, existing...

Antibiotic-resistant bacteria 'superbugs' are an emerging threat to public health due to the decrease in effective antibiotics as well as the slowed pace of development of new antibiotics to replace those that become ineffective. The need for new antimicrobial agents is a well-documented issue relating to world health. Tremendous efforts have been given to developing compounds that not only sho...

sometimes devastating diseases in humans, animals, and crops. Furthermore, resistance against antimicrobial drugs is steadily increasing. There is thus an urgent need to discover new antimicrobial drugs and drug targets. Antimicrobial peptides (AMPs) are widespread in nature and produced naturally by animals, plants, fungi, and bacteria (Zasloff, 2002). These secreted peptides typically act as ...