background: emergence of antimicrobial resistance toward a number of conventional antibiotics has triggered the search for antimicrobial agents from a variety of sources including the marine environment. objectives: the aim of this study was to evaluate the antimicrobial potential of holothuria leucospilota from qeshm and kharg islands against some selected bacteria and fungi. materials and met...

conclusions if medical treatment gets started early in the course of empyema, prognosis would be excellent. besides, there was no significant difference in short- and long-term outcomes between medical or surgical interventions. objectives the aim of this study was to compare the duration of admission, duration of intravenous antibiotic therapy, time to response to treatment, and outcomes of me...

Rapid increase in drug-resistant influenza virus isolates, and pandemic threat posed by highly pathogenic avian influenza A and swine flu viruses provide clear and compelling reasons for fast tracking development of novel antiviral drugs. Nucleic acid-based drugs represent a promising class of novel antiviral agents that can be designed to target various seasonal, pandemic and avian influenza v...

Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and ri...

Influenza A virus is one of the most important health risks that lead to significant respiratory infections. Continuous antigenic changes and lack of promising vaccines are the reasons for the unsuccessful treatment of influenza. Statins are pleiotropic drugs that have recently served as anti-influenza agents due to their anti-inflammatory activity. In this study, the effect of simvastatin on i...

In the present study, the anti-influenza A (H2N2) virus activity of patchouli alcohol was studied in vitro, in vivo and in silico. The CC₅₀ of patchouli alcohol was above 20 µM. Patchouli alcohol could inhibit influenza virus with an IC₅₀ of 4.03 ± 0.23 µM. MTT assay showed that the inhibition by patchouli alcohol appears strongly after penetration of the virus into the cell. In the influenza m...

Infections with organisms that are resistant to various anti-microbial agents pose a serious challenge to effective management of infections. Resistance to antimicrobial agents, which may be intrinsic or acquired, has been noted in a wide variety of microorganisms causing human infections. These include resistance to antiviral agents in HIV, HBV, CMV and influenza virus, anti-parasitic agents i...

The urgent need of neuraminidase inhibitors (NI) has provided an impetus for understanding the structure requisite at molecular level. Our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. The main objective of present study is to develop selective NI, with least toxicity and dru...

conclusions as a result of the full range uv-vis scanning of the responsible band in the hptlc experiments (200-700 nm), the flavonoid was the most imaginable natural compound. results through the bioassay guided fractionation method, the greatest antibacterial activities were related to the n-hexane extract. it was also revealed that the effective anti-mrsa agent of the assessed plant was a re...

background: the aim of this study was to compare the antibacterial efficacy of endemic satureja khuzistanica jamzad (skj) essential oil as root canal irrigation versus 2.5% sodium hypochlorite and 2% chlorhexidine gluconate.     methods: in current in vitro experimental study, fifty four single-rooted teeth were randomly divided into 6 groups of 9 samples: 2.5% sodium hypochlorite (naocl), 2% c...