Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in clinical practice. Since the introduction of these potent acid-suppressing agents in the late 80s, they were listed in the Guinness Book of World Records as the most prescribed in human history. Yet, to be effective in inhibiting the proton pump enzyme (H+/K+ ATPase) in the parietal cells, these drugs should be taken ...

Only recently have we been satisfied with the data obtained from recording the pH of luminal contents within the duodenal bulb in situ. The improvement in technique consisted of concurrent recording of antral and duodenal transmucosal potential differences so that the site of the electrode could be determined without fluoroscopy (Archambault, Rovelstad, and Carlson, 1967). A logical application...

Didanosine formulation that contains a buffer to prevent it from acid-mediated degradation can result in a significant decrease in the oral absorption of certain drugs because of interactions with antacids. An enteric formulation of didanosine is unlikely to cause such drug interactions because it lacks antacids. This study was undertaken to determine whether the enteric bead formulation of did...

Background: Gastroesophageal reflux disease (GERD) is a prevalent disease in Western countries. Despite effective treatment modalities, in some patients total symptom control is not achieved in clinical practice. A cross-sectional study was designed to assess primary care practitioners’ views on the effectiveness of proton pump inhibitors (PPI) as monotherapy in the control of the most common s...

THE MEDICAL therapy of peptic ulceration is at present most unsatisfactory. Some people draw a distinction between the medical treatment of gastric ulcer and that of duodenal ulcer, but we believe that this distinction is unimportant as the same general principles apply to both, apart from a few specific forms of treatment that we shall mention later. For practical clinical purposes therapy can...