an alternative in vitro approach to drug screening has been the use of human cell cultures for antiviral agents and microbial cell cultures for the assessment of the carcinogenic potential of selected compounds. a number of protozoan species have been also used as drug screens for anti-protozoal agents. the ciliated protozoan tetrahymena pyriformis species has been widely utilised as a drug scr...

Subhamay Ghosh, Michael R. Wilson, Sharmila Choudhury, Hirotoshi Yamamoto, Michael E. Goddard, Boglarka Falusi, Nandor Marczin, and Masao Takata Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London; and Department of Cardiothoracic Surgery and Anaesthetics, Imperial College London, and Heart Science Centre, Harefie...

Generally, plasma proteins owe their binding capacity to the presence of aminoacid units which enter into intra- and intermolecular hydrophobic bonding with a diverse range of endo- and exogenous chemical substances. The intermolecular interactions between the hydrophobic areas of drug molecules and those of plasma proteins play an important role in drug-macromolecular complex formation and...

D. Blackwood1, R. Santhirapala2, M. Mythen3 and D. Walker4,* 1 Department of Anaesthetics, Barnet Hospital, Royal Free Foundation Trust, London, UK, 2 Department of Anaesthetics, Royal Surrey County Hospital, Guildford, Surrey, UK, 3 Anaesthesia and Critical Care Medicine, University College London, London, UK, and 4 Department of Anaesthesia and Critical Care Medicine, University College Hospi...

BACKGROUND Distant metastasis or local recurrence after primary tumour resection remain a major clinical problem. The anaesthetic technique used during oncologic surgery is suggested to influence the metastatic process. While awaiting the results of ongoing randomised controlled trials (RCTs), we have analyzed the evidence regarding the influence of anaesthetic drugs on experimental tumour meta...

Inhalational anesthetics have been used to induce and maintain general anaesthesia for more than 150 years. These anaesthetic agents are commonly in the surgical clinical practice solely as a conjugant with other anaesthetics. Since inhalational develop amnesia, loss of awareness, reduce reactions painful stimuli, they an essential part anaesthesia. The choice agent is based on procedure's dura...