This study investigated whether the hippocampal system plays a modulatory role in the timing of conditioned responses (CRs) in eyeblink classical conditioning. Seven bitemporal amnesic patients and 7 controls were randomly presented 2 tone conditioned stimuli (CSs) that were individually paired with two different interstimulus intervals (ISIs) in a delay conditioning task. It was found that amn...

The authors examined whether perception of emotional stimuli is normal in amnesia and whether emotional arousal has the same enhancing effect on memory in amnesic patients as it has in healthy controls. Forty standardized color pictures were presented while participants rated each picture according to emotional intensity (arousal) and pleasantness (valence). An immediate free-recall test was gi...

Recently, the amnesic case D.A. was shown to circumvent his relational memory impairments, as observed in the transverse patterning (TP) task, using a self-generated unitization strategy, and such performance benefits were maintained over extended delays (Ryan et al., 2013). "Unitization" encourages fusing of distinct items, through an action, into a single unit from which the relations among t...

Hippocampal amnesia is defined by deficits in the binding of relations among items--a deficit captured by the transverse patterning (TP) task. Unitization is a processing mechanism that may allow amnesic patients to compensate for relational memory deficits. Amnesic patient D.A. demonstrated intact TP, and performance was maintained 1 month following training. Successful acquisition of relation...

Amnesia for violent offenses is common, but little is known about underlying causes or whether memory can recover. In this study, 50 violent offenders were interviewed with neuropsychological and psychometric measures, to determine the factors that underlie amnesia and the recovery of memory in these cases. The results showed that amnesia for a violent offense was associated with crimes of pass...

-Tests of new learning capacity and remote memory were given to the chronic amnesic patient (N.A.) who sustained a stab wound to the basal brain in 1960. N.A.‘s persisting defect in new learning was demonstrated with several tests, including a distractor test of short-term memory. These results are discussed in the light of previous findings in amnesic patients with distractor tests. N.A.‘s rem...

H.M., a well-known subject with bilateral removal of medial-temporal-lobe structures and profound amnesia, performed eyeblink classical conditioning (EBCC) for 21 90-trial sessions in the 400-ms delay and 900-ms trace paradigms. A 2nd amnesic subject with temporal lobe lesions and 2 normal control subjects (NCSs) were also conditioned. Acquisition occurred in both paradigms for all subjects. Ac...

Amnesic patients were studied to determine whether the acquisition and retention of item-specific skills can be supported by nondeclarative (implicit) memory. In Experiment 1, subjects read 2 different passages 3 times in succession. Reading speed improved at a similar rate in both amnesic patients and normal subjects and was specific to the text that was read. In Experiment 2, amnesic patients...

Amnesic patients and control Ss read the names of famous and nonfamous persons. Subsequently, both groups were more likely to designate a name as famous if it had been encountered previously. The facilitatory effect of prior presentation was similar for amnesic patients and control Ss and similar for famous and nonfamous names. For amnesic patients, the effect occurred despite severely impaired...

Some amnesic patients show an impairment of temporal order memory that cannot be accounted for by content memory deficits. The performance of an amnesic patient on memory tasks assessing the patient's content and temporal memories for remotely acquired material is described, after a lesion including the bilateral anterior fornix and adjacent anterior thalamus. The patient displayed a deficit in...