The California Supreme Court first recognized wrongful life in Turpin v. Sortini, and has since only permitted the child to recover special damages for the extraordinary additional medical care and training occasioned by the genetic defect. The wrongful life jury instruction under CACI requires the following elements to sustain the cause of action: 1) the defendant negligently failed to diagnos...

We conducted the present study in an attempt to correlate function with the rate of molecular evolution for serum albumin and alpha-fetoprotein. We found a high rate of silent substitution (between 5 X 10(-9) and 7 X 10(-9)/site/year) for both the albumin and alpha-fetoprotein genes, perhaps the highest so far reported for an expressed nuclear gene. The rates of effective substitution and amino...

A clonal rat fetal liver cell line that expresses the functions of differentiated liver cells under controllable conditions has been established. Normal fetal liver cells were transformed by a temperature-sensitive A (tsA) mutant (tsA209) of simian virus 40. At the permissive temperature (33 degrees C), the tsA209-transformed liver cell line (RLA209-15) can be cultured indefinitely and cloned r...

Background: The maternal serum alpha-fetoprotein test (MSAFP) was developed to screen for neural tube defects. Little is known about the adoption of the MSAFP test. This study examines the effect of provider specialty and geographic location and patient insurance status on MSAFP test use in Washington State. Methods: We conducted a retrospective cohort study of MSAFP use in low-risk obstetric p...

We report the sensitive photoelectrochemical sandwich-type immunosensing of alpha-fetoprotein by using SnO 2 /In S 3 as a novel heterojunction material and horseradish peroxidase (HRP)–CeO an efficient biolabel.

Cytology in General Practice H. C. McLaren, F.R.C.O.G..... 350 Chronic Prostatitis Surgeon Commander N. J. Blacklock, F.R.C.S., and D. S. Reeves, M.R.C.PATH. 351 Trapped Nerves W. V. Applegate, M.D............................351 Distress of Dying R. C. Lamerton, M.R.C.S......................351 Alpha-fetoprotein and Gastric Carcinoma C. M. Castleden, M.R.C.P., and J. D. Davies, M.D . .............

A purified and homogeneous preparation of rat AFP, as judged by both electrophoresis on Cellogel and immunoelectrophoresis, was separated into two components, AFPa and AFPb, by disc electrophoresis on 7% polyacrylamide gel. These two components had a definite difference in electrostatic net charge and gave only a single band on SDS-electrophoresis. Immunological reactivity or electrophoretic se...