Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators--pralidoxime, obidoxi...

We have extensively studied microbial metabolism of toxic compounds with a triple bond between carbon and nitrogen, such as nitriles [R–CN] . In the Pseudomonas chlororaphis B23 strain, nitrile is hydrated to amide by nitrile hydratase (NHase), followed by degradation to acid by amidase. This strain’s NHase was previously used for the industrial acrylamide production and is now used for the pro...

In the title compound, [Cu(C(7)H(3)NO(4))(C(6)H(6)N(2)O)(H(2)O)], the coordination geometry of the Cu(II) atom can be described as distorted square pyramidal. The basal plane is defined by one N atom and two O atoms from the deprotonated pyridine-2,6-dicarboxyl-ate ligand, and a pyridyl N atom from the 4-pyridyl aldoxime ligand. The apical position is occupied by a water mol-ecule. O-H⋯O hydrog...

Several ether and ester derivatives of aryl aldoximes have been synthesized from the aryl aldehydes. Structures of all new products were established by spectral methods. Many of the obtained compounds showed higher activity against fungal pathogens Botrytis cinerea, Fusarium culmorum, Phytophthora cactorum, and Rhizoctonia solani than the reference substance chlorothalonil, reaching 100% inhibi...

' Nine of the subject compounds have been synalog, 2,2-dimethyl-3-thiophanone 0-(methylcarthesized and evaluated for their insecticidal bamoyl)oxime, elicits a miticidal response; this properties. These materials are characterized by material is also toxic to the aphid and housefly good activity to the housefly, a lower order of efand shows a high order of systemic activity. In fectiveness agai...

In this study, reactions of quaternization under microwave heating of pyridine, α-picoline, pyridine-4-aldoxime, pyridine-2aldoxime, nicotinamide, isonicotinamide and pyridoxal oxime with different electrophiles: 2-bromo-4'-nitroacetophenone, 2-amino-4chloro-methylthiazole hydrochloride, methyl iodide, 1,3-diiodopropane and 1,3-dibromopropane are reported. The synthesis yield by microwave diele...