BACKGROUND Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incubated with conditioned media (CMs) from human breast cancer adipose tissue explants (hATT) or normal breast adipose tissue explants (hATN); 2) in hATN-CMs vs hATT-CMs; 3) in the...

In this work, we study warm inflationary scenario based on a deformation of R2 gravity. We start considering Rp and assume p=2(1+?) with ??1 so that simply obtain inflation when setting ?=0. then derive the potential in Einstein frame consider dissipation parameter form ?=C1T C1 being coupling parameter. focus only strong regime which interaction between inflaton radiation fluid has been taken ...

This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only ...

The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first described to act on the satiety center in the hypothalamus through specific receptors (leptin receptor [ObR]) to restrict food intake and enhance energy expenditure. Important peripheral actions of leptin involve inhibition of insulin biosynthesis and secretion i...

AIMS Inflammation is closely associated with the development of atherosclerosis and metabolic syndrome. Adiponectin, an adipose-derived secretory protein, possesses an anti-atherosclerotic property. The present study was undertaken to elucidate the presence and significance of adiponectin in vasculature. METHODS AND RESULTS Immunofluorescence staining was performed in aorta of wild-type (WT) ...

As an early hallmark of type 2 diabetes, the associated insulin resistance in peripheral tissues demands extra insulin production from the pancreatic b cells. Circulating glucose has long been recognized as the primary messenger, triggering acute and prolonged insulin secretion via well-defined biochemical pathways in b cells. However, additional mechanisms are in place to safeguard against lag...