I T HAS BEEN ONLY RECENTLY that significant progress has been made in the study of leukocyte kinetics and cell proliferation in acute leukemia. This became possible with the introduction of tritiated thymidine (H3TdR), a labeled precursor specffic for DNA.’ With the technic of radioautography, this labeled compound has been employed in vivo to investigate the leukemic cell cycle and cell prolif...

A monoclonal antibody specific for a common acute lymphoblastic leukemia (ALL) antigen has been generated and char acterized. This antibody (J-5) is reactive with leukemic cells from most patients with non-T-cell ALL and some patients with chronic myelocytic leukemia in blast crisis. J-5 antibody is not reactive with leukemic cells from patients with either T-cell ALL, chronic lymphocytic leuke...

The expression of three distinct myeloid-specific cell surface antigens detected by monoclonal antibodies (PMN 6, PMN 29, and AML-2-23) on acute and chronic myeloid leukemia cells is correlated with blast cell morphology and normal myeloid cell antigen display. In studies on normal peripheral blood cells, monoclonal antibodies PMN 6 and PMN 29 have previously been shown to react exclusively wit...

Patients diagnosed with inflammatory bowel disease are known to be at an increased risk of colorectal and liver cancers and of leukemia. In fact, several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases. The causal relationship, if any, remains undetermined. Patients needing a prolonged treatment with immu n...

A panel of monoclonal antibodies that bind to leukemic blast cells from patients with acute myelocytic leukemia and chronic myelocytic leukemia in blast crisis was studied for their ability to mediate complement-dependent lysis of a variety of cell populations from patients with leukemia, normal blood cells, and human leukemia cell lines. Several of these monoclonal antibodies were selectively ...