Rapidly restoring blood flow in the epicardial coronary artery after an acute obstruction is critical for limiting myocardial tissue damage and salvaging the area at risk. Minimizing the acute injury to the myocardium after an ischemic event (ie, infarct size) has been strongly correlated with improved outcome. In fact, large myocardial infarctions (MIs) have been associated with pronounced adv...

Rapidly restoring blood flow in the epicardial coronary artery after an acute obstruction is critical for limiting myocardial tissue damage and salvaging the area at risk. Minimizing the acute injury to the myocardium after an ischemic event (ie, infarct size) has been strongly correlated with improved outcome. In fact, large myocardial infarctions (MIs) have been associated with pronounced adv...

Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also bee...

Mousa and Alfirevic (2000) recently reported on the relationship between histological placental lesions and throm-bophilia status in women with adverse pregnancy outcomes. Their results are interesting (with apparently thorough thrombophilia testing performed), but their conclusion, that the results do not support an association between thrombophilias and adverse pregnancy outcome, is misleadin...