Breast cancer radioimmunoscintigraphy targeting HER2/neu expression is a growing fieldof work in nuclear medicine research. In this study, trastuzumab was successively labeledwith [67Ga] GaCl3 after conjugation with DOTA-NHS-ester.The conjugates were purified by molecular filtration, the average number ofDOTA conjugated per mAb was calculated and total concentration was determined byspectrophot...

Background: In order to obtain an anti-CD20 conjugate to be used in future therapeutic studies with therapeutic radioisotopes, 67Ga-labeled antibody was prepared as a model of metal chelated immunoconjugate for preliminary dosimetric and biodistribution studies. Materials and Methods: Rituximab was labeled with [67Ga]-gallium chloride after residulation with freshly prepared cyclic DTP...

Growth is one of the most intrinsic properties of cancer, and the diversity of growth or growth rate has a great influence upon the survival of the host. Since the first radiological measurement of the growth rate of human pulmonary neoplasms by Collins et al. (1956), many investigators reported tumour doubling time as a significant indicator for evaluating lung cancer (Schwartz, 1961; Weiss, 1...

introduction: in order to develop a radiolabeled calcitonin (ct) derivative for receptor imaging studies, ct was successively labeled with 67ga-gallium chloride. methods: the best results of the conjugation were obtained by the addition of 0.5 ml of a ct nasal pharmaceutical solution (1100 iu) to a glass tube pre-coated with dtpa-dianhydride (0.01 mg) at 25°c with continuous mild stirring for 3...

The value of different factors are examined to assess activity in 60 patients with biopsy-proven sarcoidosis. In patients with active sarcoidosis (n = 35), 67Gallium scans proved to be the most sensitive method (94 percent sensitivity), followed by serum angiotensin I converting enzyme (S-ACE) levels, chest x-ray films, and lymphocyte assays. In patients with peripheral pulmonary lesions, chest...

A case of unicentric Castleman’s disease located in the mediastinum is presented. A 20 years old male suffering from cough had an image of right hilar enlargement on chest X-ray. Thorax CT revealed multiple enlarged lymph nodes both in right paratracheal and hilar region. Radionuclide accumulation was detected by 67Ga scintigraphy. Surgical removal of lymph nodes at paratracheal region was perf...

Breast cancer radioimmunoscintigraphy targeting HER2/neu expression is a growing fieldof work in nuclear medicine research. In this study, trastuzumab was successively labeledwith [67Ga] GaCl3 after conjugation with DOTA-NHS-ester.The conjugates were purified by molecular filtration, the average number ofDOTA conjugated per mAb was calculated and total concentration was determined byspectrophot...

background: in order to obtain an anti-cd20 conjugate to be used in future therapeutic studies with therapeutic radioisotopes, 67ga-labeled antibody was prepared as a model of metal chelated immunoconjugate for preliminary dosimetric and biodistribution studies. materials and methods: rituximab was labeled with [67ga]-gallium chloride after residulation with freshly prepared cyclic dtpadianhydr...