The reduced binding of pyrimethamine to Ser108Asn (S108N) mutants of parasite dihydrofolate reductase (DHFR), which forms the basis of resistance of Plasmodium falciparum to pyrimethamine, is largely due to steric constraint imposed by the bulky side chain of N108 on Cl of the 5-p-Cl-phenyl group. This and other S108 mutants with bulky side chains all showed reduced binding to pyrimethamine and...

After 10 years of follow-up of a cohort of adolescents and young adults living in Munich, Tijssen et al (pp. 102–108) found that the persistence of affective symptoms earlier in life predicted later development of bipolar disorder in a dose–response fashion. They confirmed that although hypomanic symptoms are relatively common in adolescence, most resolve with time. In a Swedish national cohort...