نتایج جستجو برای: 549 cell line

تعداد نتایج: 1970969  

Journal: :reports of biochemistry and molecular biology 0
mahdi zahedpanah blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran mojgan shaiegan tel: +982188601572; fax: +982188601573 seyed hamidollah ghaffari tel: +982184902665; fax: +982188004140 mohsen nikbakht hematology, oncology and stem cell transplantation research center, shariati hospital, school of medicine, tehran university of medical sciences, tehran, iran. mahin nikugoftar blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran saeed mohammadi blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

background: interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. alternative treatments with herbal extracts offer insights into acute myeloid leukemia (aml) therapy. parthenolide (ptl), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (lscs) and bulk leukemic cell popul...

Journal: :Molecular cancer research : MCR 2010
Sulaiman Sheriff Marwan Ali Ayesha Yahya Khawaja H Haider Ambikaipakan Balasubramaniam Hassane Amlal

Overexpression of neuropeptide Y (NPY) and its receptor system has been reported in various types of cancers. NPY Y5 receptor (Y5R) has been implicated in cell growth and angiogenesis. However, the role of Y5R in breast cancer is unknown. To identify the role of Y5R in breast cancer, we screened several breast cancer cell lines to examine the expression of Y5R and its function in breast cancer....

Journal: :International journal of oncology 2006
Javier Cristóbal Juan C Stockert Angeles Villanueva Santiago Rello-Varona Angeles Juarranz Magdalena Cañete

Photodynamic therapy applied to cell cultures represents a widely accepted experimental method to investigate molecular mechanisms that lead to apoptotic cell death. In this context the subcellular localization of photosensitizers seems to be a significant factor in order to determine the apoptotic pathway that could be activated. We have characterized the experimental conditions that induce ap...

2017
Saber Imani Chunli Wei Jingliang Cheng Md. Asaduzzaman Khan Shangyi Fu Luquan Yang Mousumi Tania Xianqin Zhang Xiuli Xiao Xianning Zhang Junjiang Fu

MicroRNA-34a (miR-34a) plays an essential role against tumorigenesis and progression of cancer metastasis. Here, we analyzed the expression, targets and functional effects of miR-34a on epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs), such as TWIST1, SLUG and ZEB1/2, and an EMT-inducing protein NOTCH1 in breast cancer (BC) cell migration and invasion and its correl...

Journal: :Acta biochimica et biophysica Sinica 2006
Hui Tian Lin Li Xian-Xi Liu Yan Zhang

Ornithine decarboxylase (ODC), the first enzyme of polyamine biosynthesis, was found to increase in cancer cells, especially lung cancer cells. Some chemotherapeutic agents aimed at decreasing ODC gene expression showed inhibitory effects on cancer cells. In this study, we examined the effects of adenoviral transduced antisense ODC on lung cancer cells. An adenovirus carrying antisense ODC (rAd...

Journal: :Journal of Biomedicine and Biotechnology 2004
Sutapa Mukhopadhyay Salil K. Das Shyamali Mukherjee

Manganese superoxide dismutase (Mn-SOD), localized at the mitochondrial matrix, has the ability to protect cells against oxidative damage. It has been reported that low levels of Mn-SOD gene expression cause the development of certain kind of tumors. On the other hand, overexpression of Mn-SOD gene may play an important role in the development of cancer. In our study, we find that Mn-SOD activi...

2017
Jyoti Goutam Gunjan Sharma Vinod K. Tiwari Amrita Mishra Ravindra N. Kharwar Vijayakumar Ramaraj Biplob Koch

The present study aimed at characterizing biological potentials of endophyte Aspergillus terreus JAS-2 isolated from Achyranthus aspera. Crude extracted from endophytic fungus JAS-2 was purified and chemically characterized by chromatographic and spectroscopic studies respectively. Spectral assignment of NMR (nuclear magnetic resonance) data, 1H proton and 13C carbon analysis along with FTIR da...

Journal: :Pharmaceutical biology 2013
Kirankumar Hullatti Namrata Pathade Yuvaraj Mandavkar Ashok Godavarthi Mahesh Biradi

CONTEXT The ethanol extracts and their fractions of three Indian medicinal plants, Ervatamia coronaria (Jacq.) Stapf, (Apocynaceae), Mimosa pudica L. (Mimosaceae) and Caesalpinia bonduc (L.) Roxb. (Caesalpiniaceae) were tested for their cytotoxic activity in the brine shrimp lethality (BSL) bioassay and in various cancer cell lines. The plants were selected based on their traditional use in the...

Journal: :modares journal of medical sciences: pathobiology 2008
parvaneh nikpour seyed mehdi jafarnejad mahdi forouzandeh seyed javad mowla

objective: nucleostemin (ns) is a recently identified gene that is expressed mainly in the nucleoli of neuronal, embryonic and mesenchymal stem cells which plays a role in their self renewal. over expression of this gene has been reported in several cancer cell lines tumoral tissues including gastric, hepatic and prostate cancer. in this study, we investigated the effects of suppression of this...

Journal: :basic and clinical cancer research 0
behzad foroutan 1.department of medical sciences, school of life sciences, university of bradford, bradford, bd7 1dp, united kingdom, department of pharmacology, school of medicine, semnan university of medical sciences, semnan, iran diana anderson department of medical sciences, school of life sciences, university of bradford, bradford, united kingdom

background : the development of chemoresistance represents a major obstacle in the successful treatment of cancers such as non-hodgkin’s lymphoma (nhl). with the recognition of important roles for both p53 and its more recently described paralog p73 in mediating the activity of anti-cancer drugs, there has been increasing recognition that cellular resistance to anthracyclines could and does a...

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