نتایج جستجو برای: 246 trichloroquinoline bis2 4 dichloroquinolinemethane

تعداد نتایج: 1308549  

Journal: :Antimicrobial agents and chemotherapy 2013
Janet M Leeds Frederique Fenneteau Nathalie H Gosselin Mohamad-Samer Mouksassi Nastya Kassir J F Marier Yali Chen Doug Grosenbach Annie E Frimm Kady M Honeychurch Jarasvech Chinsangaram Shanthakumar R Tyavanagimatt Dennis E Hruby Robert Jordan

Although smallpox has been eradicated, the United States government considers it a "material threat" and has funded the discovery and development of potential therapeutic compounds. As reported here, the human efficacious dose for one of these compounds, ST-246, was determined using efficacy studies in nonhuman primates (NHPs), together with pharmacokinetic and pharmacodynamic analysis that pre...

Journal: :Journal of virology 2011
Scott K Smith Josh Self Sonja Weiss Darin Carroll Zach Braden Russell L Regnery Whitni Davidson Robert Jordan Dennis E Hruby Inger K Damon

Smallpox preparedness research has led to development of antiviral therapies for treatment of serious orthopoxvirus infections. Monkeypox virus is an emerging, zoonotic orthopoxvirus which can cause severe and transmissible disease in humans, generating concerns for public health. Monkeypox virus infection results in a systemic, febrile-rash illness closely resembling smallpox. Currently, there...

2007
Eric R. Pedersen

Objective: The authors examined the phenomenon known to college students as prepartying, which is the consumption of alcohol prior to attending an event or activity (eg, party, bar, concert) at which more alcohol may be consumed. Participants: To explore the extent of this behavior, the authors surveyed 227 college students about each drinking event over a 1-month period. Results: Principal res...

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