BACKGROUND Aging is a major risk factor for the development of atherosclerosis and coronary artery disease. Through a microarray approach, we have identified a microRNA (miR-217) that is progressively expressed in endothelial cells with aging. miR-217 regulates the expression of silent information regulator 1 (SirT1), a major regulator of longevity and metabolic disorders that is progressively ...

Analysis of our microRNA (miRNA) expression signature of pancreatic ductal adenocarcinoma (PDAC) revealed that microRNA-217 (miR-217) was significantly reduced in cancer tissues. The aim of this study was to investigate the antitumor roles of miR-217 in PDAC cells and to identify miR-217-mediated molecular pathways involved in PDAC aggressiveness. The expression levels of miR-217 were significa...

MiR-217 is a well-known tumor suppressor, and its down-regulation has been shown in a wide range of solid and leukaemic cancers. However, the biological role of miR-217 in psoriasis pathogenesis, especially in keratinocyte hyperproliferation and differentiation, is not clearly understood. In this study, we found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of...

This study found that long-term exposure of chronic myelogenous leukemia (CML) K562 cells to BCR/ABL thyrosine kinase inhibitors (TKI) caused drug-resistance in association with an increase in levels of DNA methyltransferases (DNMT) and a decrease in levels of microRNA miR-217. These observations are clinically relevant; an increase in levels of DNMT3A in association with downregulation of miR-...

Tarihi 13. yüzyıla dayanan Hz. Ali cenknâmeleri Türk halk edebiyatının önemli kaynaklarından biridir. edebiyatına Arap ve Fars edebiyatından geçmiştir. Özellikle İranlılar tarafından yazılan hakkındaki hikâyeler zamanla yaygınlaşmış epeyce beğenilmiştir. Cenknâme benzeri eserler Hayber Kalesi'nin fethinden sonra yazılmaya başlanmış bir gelenek halinde yüzyıllarca devam etmiştir. Türklerin cenkn...

MicroRNA array analysis revealed that miR-217 expression was decreased in anti-cancer drug-resistant Malme3MR cancer cells. CAGE, a cancer/testis antigen, was predicted as a target of miR-217. Luciferase activity and ChIP assays revealed a negative feedback relationship between CAGE and miR-217. miR-217 and CAGE oppositely regulated the response to anti-cancer drugs such as taxol, gefitinib and...

(a) First realize that [8] = [3] in Z5. Take different powers of [8] until we arrive at [8] = [1]. This will help us to significantly simplify [8]. [8] = [3] = [9] = [4]; [8] = [8][8] = [8][4] = [3][4] = [2]; [8] = [8][8] = [2][3] = [1]. Hence [8] = [1]. Now 391 = (97) · 4 + 3. Thus [8] = [8](97)·4+3 = [8](97)·4[8]3 = ([8])[8] = [1][8] = [8] = [2]. Therefore the remainder when 8 is divided by 5...

DNA methyltransferase 1 (DNMT1) is a major epigenetic regulator associated with many biological processes. However, the roles and mechanisms of DNMT1 in skin aging are incompletely understood. Here we explored the role of DNMT1 in human skin fibroblasts senescence and its related regulatory mechanisms. DNMT1 expression decreased in passage-aged fibroblasts and DNMT1 silencing in young fibroblas...