Infection of bovine T cells and B cells with the intracellular protozoan parasite Theileria parva induces a transformed phenotype with characteristics comparable to leukemic cells. The transformed phenotype reverts on drug-induced parasite death, and the cured lymphocytes acquire a resting phenotype and eventually die by apoptosis if not further stimulated. Here, we show that both lymphocyte pr...

Genome-scale metabolic models (GEMs) have been widely used to design cell factories in silico. However, initial flux balance analysis only considers stoichiometry and reaction direction constraints, so it cannot accurately describe the distribution of under control various regulatory mechanisms. In recent years, by introducing enzymology, thermodynamics, other multiomics-based constraints into ...

Conventional development of multivariate gene expression models (GEM) predicting therapeutic response of cancer patients is based on analysis of patients treated with specific regimens, which limits generalization to different or novel drug combinations. We overcome this limitation by developing GEMs based on in vitro drug sensitivities and microarray analyses of the NCI-60 cancer cell line pan...

Conventional development of multivariate gene expression models (GEM) predicting therapeutic response of cancer patients is based on analysis of patients treated with specific regimens, which limits generalization to different or novel drug combinations. We overcome this limitation by developing GEMs based on in vitro drug sensitivities and microarray analyses of the NCI-60 cancer cell line pan...

INTRODUCTION The Helicopter Emergency Medical Service (HEMS) was established for the prehospital trauma care of patients. Improved rescue times and increased coverage areas are discussed as specific advantages of HEMS. We recently found evidence that HEMS exerts beneficial effects on outcomes for severely injured patients. However, it still remains unknown which group of trauma patients might b...

Gas electron multipliers (GEMs) have been overcoated with a high resistivity 10 14 −10 15 Ω/ amorphous carbon layer. The coating avoids charging up of the holes and provides a constant gain immediately after switching on independent of the rate. The gain uniformity across the GEM is improved. Coating opens the possibility to produce thick GEMs of very high gain.

The paper presents an algorithm for reconstructing Geometric Element Modeling System ( ~ E ~ ~ l b a s e d industrial objects using line photogrammetry (LP) in order that there can be direct interaction between GEMS and a vision system. In the GEMS system, each object is constructed by Boolean set operators of constant solid geometry (CSG) primitives, each face of which is described by a Bounda...

BACKGROUND Transportation by helicopter may reduce time to hospital admission and improve outcome. We aimed to investigate the effect of transport mode on mortality, disability, and labour market affiliation in patients admitted to the stroke unit. METHODS Prospective, observational study with 5.5 years of follow-up. We included patients admitted to the stroke unit the first three years after...