The recent observation that certain antibiotics depress or even temporarily eliminate the bacterial reduction of bilirubin in the colon suggested that the feces under such circumstances might be an excellent source of bilirubin. The possibility was also at hand that bilirubin labeled with N15 or Cl3 might thus be made available in significant amounts, assuming a prior administration of isotopic...

Hemoconcentration is observed in bed rest studies, descent from altitude, and exposure to microgravity. Hemoconcentration triggers erythrocyte losses to subsequently normalize erythrocyte concentration. The mechanisms of erythrocyte loss may involve enhanced hemolysis, but has never been measured directly in bed rest studies. Steady-state hemolysis was evaluated by measuring two heme degradatio...

The methods described two decades ago (l-3) for the isolation of crystalline stercobilin or urobilin from feces or urine are relatively slow and cumbersome. It is often desirable to obtain a few mg of crystalline material quickly, either to permit determination of the preponderant type (whether stercobilin, urobilin, or d-urobilin) or calibration of a quantitative method. More recently, the stu...

In separate communications (1, 2), a method is described for the approximate analysis of mixtures of the urobilin group as to proportions of clor i-urobilins or Z-stercobilin. This is an adaptation of the FeClrHCl and heat procedure as first employed by Fischer and Niemann (3) for the preparation of mesobiliviolin from mesobilirubinogen, and later by Legge (4), in analyzing mixtures of I-sterco...

Aution Max AX-4280, an automated urine test-strip analyser, was evaluated in three centres. Method comparison, imprecision, carry-over, linearity, detection limit and drift studies were performed for glucose, protein, blood and leukocytes using Uriflet S 9UB strips. These strips enable measurement of pH, glucose, protein, blood, leukocytes, ketones, bilirubin, urobilinogen and nitrite. Specific...

INTRODUCTION Preanalytical specifications for urinalysis must be strictly adhered to avoid false interpretations. Aim of the present study is to examine whether the preanalytical factor 'time point of analysis' significantly influences stability of urine samples for urine particle and dipstick analysis. MATERIALS AND METHODS In 321 pathological spontaneous urine samples, urine dipstick (Urisy...

A new sensitive nitrite test, the SRN test, was evaluated for its suitability as a reliable screening technique for the detection of bacteriuria. The SRN test was compared to a currently available nitrite test, the Microstix nitrite test, and the results obtained with both nitrite tests were assessed in comparison with the results of the quantitative culture method. Of 158 cases of significant ...