Aim of this study was to evaluate the biotransformation of simple phenols after ingestion of edible fruits and mixed food. It was analyzed hippuric acid in urine as biomarker of conjugation in the liver cells of glycine with aromatic phenolic acids such benzoic and salicylic acid from ingested food. Measurement of hippuric acid in urine samples of 10 healthy individuals: 5 female and 5 male wit...

A simple method for the simultaneous determination of hippuric acid and benzoic acid in urine using reversed-phase high performance liquid chromatography was described. Chromatography was performed on a Nova-Pak C18 (3.9 x 150 mm) column with a mobile phase of mixed solution methanol: water: acetic acid (20:80:0.2) and UV detection at 254 nm. The calibration curve was linear within concentratio...

The urinary excretion of hippuric acid and methylhippuric acid was studied in workers (233 subjects; 122 men and 111 women) exposed to toluene and xylenes in combination and in non-exposed controls (281 subjects; 141 men and 140 women) recruited from the same factories or factories of the same regions. Smoking and drinking habits of the subjects were obtained by medical interviews. From each wo...

Epidemiologic studies have suggested the association between environmental exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) and the increased risk of incurring asthma. Yet there is little data regarding the relationship between personal exposure to air pollution and the incidence of asthma in children. This study was designed to evaluate the effect of ex...

At present the view is commonly accepted that hippuric acid is produced chiefly by the kidney in most animals and exclusively by that organ in the dog. This conclusion is based largely on the well known work of Bunge and Schmiedeberg (1) who were able to dem0nstrat.e that hippuric acid was formed when blood containing benzoic acid and glycine was perfused through dog kidney. Furthermore, they f...

In a recent study (1) it was found that the synthesis of hippuric acid is markedly diminished in various diseases of the liver especially those in which jaundice is present. These results are all the more interesting because in spite of the extensive research that has been done on hippuric acid, little attention has hitherto been given to the effect of liver damage. The discovery of Bunge and S...

SummaryBackground Urinary tract infections (UTIs) are among the most common hospital-acquired infections, with an estimated 75% of UTIs caused by urinary catheters. In addition to significant healthcare costs and patient morbidity, escalating antimicrobial resistance reported uropathogens make investigation efficacious new strategies urgent importance. Aim To examine ...

A method using thin-layer chromatography is described to determine the concentration of hippuric acid, mandelic acid, and phenylglyoxylic acid present in the urine after occupational mixed exposure to toluene and styrene. These substances are known metabolites of toluene and styrene, and therefore the evaluation to mixed exposure to toluene and styrene may be carried out separating these metabo...