Chronic acid loads are an obligate consequence of the high animal/grain protein content of the Western diet. The effect of this diet-induced metabolic acidosis on bone mass is controversial. In a randomized, prospective, controlled, double-blind trial, 161 postmenopausal women (age 58.6 +/- 4.8 yr) with low bone mass (T score -1 to -4) were randomly assigned to 30 mEq of oral potassium (K) citr...

Lactating beef cows (16 Hereford and 34 Angus, 430 kg average body weight, aged 8 to 10 yr) were fed a basal diet containing 200 micrograms/g Al alone or supplemented with Al-citrate, citric acid, soil or soil plus citric acid for 56 d. Diets containing Al-citrate, soil and soil plus citric acid contained 1,730, 1,870 and 1,935 micrograms/g Al, dry-basis, respectively. Adding soil to the diet a...

Urine volume is the greatest risk factor for nephrolithiasis. High fluid intake is the first general advice given to stone-forming patients for the prevention of their recurrence. The aim of the present study was to evaluate the influence of bicarbonate-rich mineral water (1715 mg bicarbonate/l) on urinary-stone risk factors in comparison with sodium potassium citrate, a well-established treatm...

Urinary calculus is a common disease. Potassium citrate is usually used to prevent lithangiuria. Urinary calculus formation is affected by sex hormone. This study investigated the preventive and therapeutic effect of potassium citrate combined estradiol on lithangiuria. SD rats were randomly divided into three groups, control group, model group established by administration of 3% melamine (Mel)...

There are rising public health concerns about the links between consumption of sugar-sweetened beverages and weight gain, obesity, and other metabolic problems. Sodium citrate (Na-citrate) is used as an additive in colas and various commercial drinks worldwide. Although potassium citrate (K-citrate) has been prescribed and well accepted by urologists for treating urinary stone disease (urolithi...

A relation between vitamin D and citrate metabolism has been clearly established by various investigators, the first of whom was Dickens (l), followed by Nicolaysen and Nordbo (2), Harrison and Harrison (3), Freeman and Chang (4), Waasjo and &g-Larsen (5)) and Carlsson and Hollunger (6). In this laboratory, interest in citrate metabolism was aroused by the finding of citrate lithiasis in rats o...

Introduction Uroliths are concretions formed in the urinary tract. These can be problematic humans and companion animals such as cats. Magnesium ammonium phosphate (struvite) calcium oxalate (CaOx) most common forms of uroliths. The relative supersaturation (RSS) is a risk index crystal formation. Here, an updated program for calculating RSS, EQUIL-HL21, was used to detect differences RSS value...

Abstract. – Urinary stones have been recognized as a human disease since dawn of history and treatment of this condition is reported by Egyptian medical writings. Also, pears have a very long history, being one of the earliest cultivated fruit trees and also known for medicinal use. Urinary tract stone formation represents a common condition and also a significant burden for health care service...

Chronic metabolic acidosis increases proximal tubular citrate uptake and metabolism. The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase. Chronic metabolic acidosis caused hypocitraturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d. Renal cortical ATP citrate lyase protein abundan...

Chronic metabolic acidosis increases proximal tubular citrate uptake and metabolism. The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase. Chronic metabolic acidosis caused hypocitraturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d. Renal cortical ATP citrate lyase protein abundan...