Guidelines urge general practitioners (GPs) to discuss smoking with patients as frequently as possible. Using data collected before and after consultations, this study confirms that GPs are more likely to discuss smoking in the context of smoking-related problems. Encouraging GPs to make greater use of problem-orientated opportunities to discuss smoking may have more effect on rates of advice g...

AIMS The study was undertaken to investigate if there are specific identifiable risk factors on the preoperative history or urodynamics testing associated with an increased risk for the development of symptoms of de novo urge urinary incontinence after a minimally invasive sling procedure. METHODS Two hundred eighty-one women who had undergone minimally invasive sling surgery for stress urina...

PURPOSE Trospium chloride is an anticholinergic agent with predominantly peripheral nonselective antimuscarinic activity lacking central nervous system effects. It has no known drug-drug interactions, an advantage for patients taking many medications. Because these qualities may provide added benefit when treating patients with symptoms associated with overactive bladder (OAB) and urge incontin...

We describe the development of a user interface for a mobile museum guide based on handheld devices. The system provides audio, video, graphics and text content to visitors of a world cultural heritage site, the “Weltkulturerbe Völklinger Hütte”[2]. The focus of this paper is on the design process and how the user interface was adapted step by step in order to meet the needs of visitors and acc...

Urge to merge erects filopodia rawling cells often produce both broad, flat lamellipodia and long, thin filopodia. Once formed, both structures appear to use an actin-treadmilling mechanism to extend themselves. During treadmilling, lamellipodia continuously nucleate new filaments, but filopodia continue to use the same filaments. So how does a cell form a filopodium in the first place? Svitkin...

BACKGROUND The current study assessed dose-dependent effects of alcohol compared with placebo on ratings of urge to smoke in light smokers. METHODS Sixteen nonalcoholic social drinker-smokers were tested individually in three separate early evening sessions where they received a placebo (with 1% ethanol as a taste mask), a low-dose (0.4 g/kg) alcoholic beverage, or high-dose (0.8 g/kg) alcoho...

OBJECTIVE The goal of this project was to determine if mechanical stimulation to the posterolateral oropharynx would elicit the urge-to-cough and/or cough. BACKGROUND Inhaled agents, such as capsaicin and citric acid, readily produce coughing and the sensation of urge-to-cough. Areas below the glottis are thought to be the primary sensory mediators of these responses, however it is unknown if...