OBJECTIVE The proportion of tuberculin reactors in a population and the intensity of tuberculin reactions have been shown to increase with increasing exposure to mycobacterial infection, eg, repeated BCG immunization. These observations suggested that tuberculin reactivity would become uniformly high in individuals with a high mycobacterial load who did not have a known cause of anergy. Since t...

Seibert (1930) found that the tuberculin proteins of the three varieties of tubercle bacillus could be distinguished by the precipitin test. If this method could be adapted for identifying tubercle bacilli, it would be preferable to animal inoculation. The behavior of the tuberculin proteins of acid-fast bacteria in the precipitin test is interesting not only as a possible means of identificati...

Isoniazid chemoprophylaxis is not recommended for all persons infected with tubercle bacilli. Because of the small but significant risk of isoniazid hepatotoxicity, chemoprophylaxis is reserved for only those at the highest risk of tuberculosis activation. To evaluate this policy, we performed a cost-effectiveness analysis of isoniazid chemoprophylaxis for two populations with positive tubercul...

BACKGROUND M. tuberculosis remains one of the world's deadliest pathogens in part because of its ability to establish persistent, latent infections, which can later reactivate to cause disease. In regions of the globe where disease is endemic, as much as 50% of the population is thought to be latently infected, complicating diagnosis and tuberculosis control. The tools most commonly used for di...

tuberculosis (tb) is an important health problem in developing countries, with varying clinical presentations depending on the organs/systems involved. to study the spectrum of clinical and paraclinical aspects of extra pulmonary tb in children suffering from pulmonary tb. this study has been carried out on 65 children with tuberculosis, admitted in tb wards of national research institute of tu...

current guidelines suggest that the ppd mantoux tuberculin test should be read after 48 or 72 hours. we have compared the measurements at these time points. a 5-tuberculin unit (tu) ppd mantoux test was administered to 100 subjects (91% with bacillus calmette- guerin scars). induration was measured 48 and 72 hours following the injection. results the measurements made at 72nd hour were signific...

Aim: To determine the prevalence of tuberculosis among traditional milking cows in southern Zambia and isolation of Mycobacterium spp from the tuberculin positive cow's milk. Materials and Methods: A total of 1,025 cows originating from traditional cattle sector, in Mapepe, Magoye, Monze, Batoka, GARTBatoka, Kalomo areas of Zambia, supplying major quantity of milk to milk processors, were teste...

(Received for publication, December 24, 1957) In tuberculous cases of children, the erythrocytes sensitized with tuberculinpolysaccharide were detected by means of the agglutination reaction between the erythrocytes and the immune serum prepared in the following way. Sheep were treated by repeated injection of killed tubercle bacilli, until the serum ob tained from same was able to cause an agg...