Toxicological data or PBPK models were not available for any of the threeor four-component submixtures. Toxicological data were available only for the binary mixture of carbon monoxide and methylene chloride; toxicological data on the other binary submixtures were not located. PBPK models for methylene chloride generally contain components describing the metabolism of methylene chloride to form...

Note: A TOXICOLOGICAL REVIEW is available for this chemical in Adobe PDF Format (153 pp, 905K). Similar documents can be found in the List of Available IRIS Toxicological Reviews. Links to specific pages in the toxicological review are available throughout this summary. To utilize this feature, your Web browser and Adobe program must be configured properly so the PDF displays within the browser...

BACKGROUND Regulatory agencies in the United Kingdom and the United States have recently issued warnings about a possible link between suicidal ideation and attempts and the use of paroxetine in a pediatric patient population. The objective of this study was to determine the proportion of youth suicides that tested positive for paroxetine or other antidepressants in medical examiner toxicologic...

By exploiting data from the Toxic Release Inventory of the United States, we have established that the toxicological footprint (TF) increased by 3.3% (88.4 Mt) between 1998 and 1999 and decreased by 39% (1088.5 Mt) between 1999 and 2013. From 1999 to 2006, the decreasing TF was driven by improvements in emissions intensity (i.e. gains in production efficiency) through toxic chemical management ...

The mechanistic relationship of the inhibition of gap junctional intercellular communication (GJIC) to other toxicological phenomena was explored using a recently developed method that models the properties of a large population of molecules chosen to represent the 'universe of chemicals'. The analyses indicate that inhibition of GJIC is strongly linked to the carcinogenic process in rodents, t...

The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various toxicogenomic technologies to predict potential for toxicity and prioritize limited testing resources toward chemicals that likely represent the greatest hazard to human health and the environment. This chemical prioritization research program,...

OBJECTIVE To evaluate the impact of the application of the "Pesticides Law" (Law no. 7,802/89) on the toxicological classification profile of registered pesticides in Brazil, from 1990 to 2000. METHODS Data on registered commercial products in the years 1990 and 2000 were analyzed according to toxicological class, date of registration of the active ingredient (before or after the Law) and usa...