Abstract Traditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation RT course, using population-wide estimates for patients’ response to therapy. However, recent technological advancements have enabled monitoring individual patient during in form biomarkers. Although biomarker data remains subject substantial uncertainties, information extracted fr...

INTRODUCTION Results on the evolution of the clinical status of patients undergoing cardiac resynchronization therapy with a defibrillator after automatic optimization of their cardiac resynchronization therapy are scarce. We observed a rapid and important change in the clinical status of our non-responding patient following activation of a sensor capable of weekly atrioventricular and interven...

Ventricle to ventricle (VV) delay optimization can provide an additional benefit to cardiac resynchronization therapy, but the methods currently used for optimization are time consuming and operator-dependent. We present two cases of VV-delay optimization with the use of a new intracardiac electrogram method. (Cardiol J 2007; 14: 305-310).

New oral anticoagulants (NOACs) have been introduced to improve anticoagulant therapy worldwide, but safe implementation may require additional measures. First, optimization of dose adjustment based on therapeutic levels of the drug may be more appropriate than fixed dose therapy. The development and implementation in quantitative laboratory assays will enable further dose optimization. Second,...

To improve the human arm function of disable patients after stroke, we propose in this paper a new design of a robot-assisted therapy. The robotic device must be attached to a human arm and mimics the motion of the shoulder, elbow and wrist joints. The functional training of the stroked upper limb is covered in motion and force via a safe compliant motion. The controller parameters are optimize...

AIMS For successful cardiac resynchronization therapy (CRT), an optimization of left ventricular (LV) lead position and stimulation timing is required. The feasibility of optimizing LV lead position, atrioventricular delay (AVd), and interventricular delay (VVd) in CRT using intracardiac impedance measurement was evaluated. METHODS AND RESULTS Heart failure patients (n = 14, NYHA 13×III, 1×II...