نتایج جستجو برای: thalassemic

تعداد نتایج: 1036  

Journal: :The Journal of clinical investigation 1974
G Cividalli D G Natham H F Lodish

Previous studies of beta-thalassemic reticulocytes have implied a decreased amount of functional beta-mRNA but unimpaired translation of the beta-mRNA present. However, the beta/alpha synthetic ratios in beta-thalassemic marrow are higher than those observed in reticulocytes of the same patients. This could imply that marrow cells contain an abnormally functioning beta-mRNA no longer active in ...

Journal: :international journal of hematology-oncology and stem cell research 0
hamid choobineh department of medical laboratory sciences, faculty of para- medicine, tehran university of medical sciences sj dehghani department of medical laboratory sciences, faculty of para- medicine, tehran university of medical sciences shaban alizadeh department of hematology and blood banking, faculty of para- medicine, tehran university of medical sciences v ghobadi dana department of pediatrics, faculty of medicine, tehran university of medical sciences n saiepour department of biochemistry, faculty of medicine, tehran university of medical sciences r meshkani department of epidemiology and biostatistics, school of public health, tehran university of medical sciences

introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...

2010
Zohreh Sharifi Saeideh Milani Mahmood Mahmoodian Shooshtari

OBJECTIVE In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS To assess the efficacy of immunization and determine the immune response of children with beta-thalasse...

Journal: :Acta biochimica Polonica 2016
Asem Metwally Abo-Shanab Mohamed Ali El-Desouky Naglaa Mohamed Kholoussi Ghada Youssef El-Kamah Iman Aly Helwa Abdelgawad Ali Fahmi

UNLABELLED This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia. MATERIALS AND METHODS The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, gr...

Journal: :Blood 1996
M Aljurf L Ma E Angelucci G Lucarelli L M Snyder C R Kiefer J Yuan S L Schrier

The life threatening anemia in beta-thalassemia major (Cooley's anemia) is characterized by profound intramedullary lysis, the cause of which is incompletely understood. Using marrow obtained from beta thalassemia major patients undergoing allogeneic bone marrow transplantation in Pesaro Italy, it became possible to directly study the mechanism of the intramedullary hemolysis. Based on our prev...

Journal: :Blood 1990
C R Zerez N A Lachant K R Tanaka

We have examined aspects of methemoglobin (metHb) reduction in sickle and in thalassemic red blood cells (RBCs). NADH metHb reductase activity in sickle and thalassemic RBCs was significantly increased compared with normal RBCs. Because in vitro enzyme activity does not necessarily represent in vivo activity, we measured the rate of metHb reduction in intact RBCs. Intact thalassemic RBCs demons...

Journal: :medical journal of islamic republic of iran 0
t zandieh from the iranian blood transfusion service, tehran f tarabadi from the iranian blood transfusion service, tehran a tabatabaiyan from the iranian blood transfusion service, tehran m izadyar the department of hematology, pediatric medical center, tehran university of medical sciences, tehran, i.r. iran.

the aim of this study was to evaluate the immune system and lymphocyte function in 41 iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. the patients consisted of 20 splenectomized and 21 non-splenectomized patients. they were treated with desferal, and had received repeated blood transfusion. laboratory investigations included measurement of total t lymphocytes, a...

Journal: :journal of basic research in medical sciences 0
farajolah maleki clinical microbiology research center mitra azizian department of neursing masoumeh shohani department of physiology mansour amraei

introduction: the coagulation factor 13 has a fundamental role in homeostasis, protective effects on thrombosis, and some other associated diseases. due to increasing the chronic coagulability of major thalassemic patients, this study was conducted with aim determining the prevalence of val34leufxiii polymorphism in the thalassemic patients. materials and methods: the present case-control study...

2017
Raman Bahal Dale L. Greiner Michael A. Brehm Peter M. Glazer Nicole Ali McNeer Elias Quijano Yanfeng Liu Parker Sulkowski Audrey Turchick Yi-Chien Lu Dinesh C. Bhunia Arunava Manna Christopher J. Cheng Francesc López-Giráldez Adele Ricciardi Jagadish Beloor Diane S. Krause Priti Kumar Patrick G. Gallagher Demetrios T. Braddock W. Mark Saltzman Danith H. Ly

In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery" (2016).

2002
Carlos M. de Castro Blythe Devlin

Mutations within exon 3 of the @-globin gene are relatively uncommon, and many of these mutations produce a dominant thalassemia-like phenotype. We describe a novel thalassemic hemoglobinopathy caused by a single nucleotide substitution (CTG + CCG) at codon 1 14 resulting in a leucine to proline substitution and designate it @Durham-NC B1 14 Leu + Pro]. The mutation producing this thalassemic h...

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