نتایج جستجو برای: thalassemic
تعداد نتایج: 1036 فیلتر نتایج به سال:
Previous studies of beta-thalassemic reticulocytes have implied a decreased amount of functional beta-mRNA but unimpaired translation of the beta-mRNA present. However, the beta/alpha synthetic ratios in beta-thalassemic marrow are higher than those observed in reticulocytes of the same patients. This could imply that marrow cells contain an abnormally functioning beta-mRNA no longer active in ...
introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...
OBJECTIVE In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS To assess the efficacy of immunization and determine the immune response of children with beta-thalasse...
UNLABELLED This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia. MATERIALS AND METHODS The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, gr...
The life threatening anemia in beta-thalassemia major (Cooley's anemia) is characterized by profound intramedullary lysis, the cause of which is incompletely understood. Using marrow obtained from beta thalassemia major patients undergoing allogeneic bone marrow transplantation in Pesaro Italy, it became possible to directly study the mechanism of the intramedullary hemolysis. Based on our prev...
We have examined aspects of methemoglobin (metHb) reduction in sickle and in thalassemic red blood cells (RBCs). NADH metHb reductase activity in sickle and thalassemic RBCs was significantly increased compared with normal RBCs. Because in vitro enzyme activity does not necessarily represent in vivo activity, we measured the rate of metHb reduction in intact RBCs. Intact thalassemic RBCs demons...
the aim of this study was to evaluate the immune system and lymphocyte function in 41 iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. the patients consisted of 20 splenectomized and 21 non-splenectomized patients. they were treated with desferal, and had received repeated blood transfusion. laboratory investigations included measurement of total t lymphocytes, a...
introduction: the coagulation factor 13 has a fundamental role in homeostasis, protective effects on thrombosis, and some other associated diseases. due to increasing the chronic coagulability of major thalassemic patients, this study was conducted with aim determining the prevalence of val34leufxiii polymorphism in the thalassemic patients. materials and methods: the present case-control study...
In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery" (2016).
Mutations within exon 3 of the @-globin gene are relatively uncommon, and many of these mutations produce a dominant thalassemia-like phenotype. We describe a novel thalassemic hemoglobinopathy caused by a single nucleotide substitution (CTG + CCG) at codon 1 14 resulting in a leucine to proline substitution and designate it @Durham-NC B1 14 Leu + Pro]. The mutation producing this thalassemic h...
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