Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

Purpose Students' perception towards learning technologies in the disruptive times like coronavirus disease (2019) COVID-19 is what educational institutes are striving to know so that could provide best experiences students. The present study attempts identify technology-enhanced (TEL) factors (i.e. informational quality, compatibility, resource availability, self-efficacy, subjective norms, su...

The leukemia-associated fusion protein MN1-TEL combines the transcription-activating domains of MN1 with the DNA-binding domain of the transcriptional repressor TEL. Quantitative photobleaching experiments revealed that ∼20% of GFP-tagged MN1 and TEL is transiently immobilised, likely due to indirect or direct DNA binding, since transcription inhibition abolished immobilisation. Interestingly, ...

The t(12;21)(p13;q22) results in the fusion of the TEL gene located on chromosome 12 with the AMLI gene located on the derivative chromosome 21. Because this translocation is difficult to detect using standard cytogenetic techniques, 27 previously karyotyped Blineage acute lymphoblastic leukemia (ALL) cell lines were evaluated for the presence of the EL-AMLI fusion using the reverse transcripta...

Defects are crucial in determining the overall physical properties of semiconductors. Generally, charge-state transition level (TEL), one key quantities that determines dopability defects semiconductors, is temperature dependent. However, little known about dependence TEL, and, as a result, almost all existing defect theories semiconductors built on temperature-independent approximation. In thi...

As technology continues to shape the landscape of education, need for effective evaluation frameworks sustainable technology-enhanced learning (TEL) becomes increasingly vital. This study presents an expert-opinion-based framework, utilizing Z-numbers and fuzzy logarithm methodology additive weights (LMAW), assess sustainability TEL approaches. framework focuses on four main criteria: cloud ser...