nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...

conclusions dlec1 suppresses tumor cell growth the presence of ap-2α2 and stimulates cell proliferation in the down-regulation of ap-2α2 in dlec1 over-expression stable clones of htc116. results the dlec1 over-expression was found to reduce the number of colonies in colony formation and to induce g1 arrest in seven clones, and apoptosis in one clone in the cell cycle analysis. furthermore, rega...

objective(s):mir-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (gct) of bone remains poorly understood. the current study aimed to investigate the potential role and mechanism of mir-125b in gct. materials and methods:expression levels of mir-125b in gct tissues were determined using rt-pcr. the cell proliferation was surveyed by direct cell coun...

background: tuberculosis (tb) remains an important health problem throughout the world. despite its significance in public health, mechanisms of protective immunity against mycobacyerium tuberculosis in humans have not yet been understood. objective: to evaluate cell mediated immune response against purified ag 85, ppd and phytohemagglutinin (pha) in patients with tuberculosis and healthy tuber...

runx3, a member of runt-related transcription factor (runx) proteins with tumor suppressor effect, is a tissue–restricted and cancer related transcription factor that regulate cell proliferation and growth, as well as differentiation. in the present study, exogenous run3 was transiently expressed in ags (human gastric adenocarcinoma), with undetectable runx3 protein and in a549 (human lung carc...

background micrornas are small and non-coding rna molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mrna. mir-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. one of its best known functions is apoptosis that affects on caspase-3 activity. the main aim ...