Orofacial granulomatosis (OFG) is an uncommon disease characterized by persistent or recurrent soft tissue enlargement, oral ulceration and a variety of other orofacial features. It could be an oral manifestation of a systemic disease. For a correct differential diagnosis, local and systemic conditions characterized by granulomatous inflammation should be excluded using appropriate clinical and...

INTRODUCTION Subcutaneous sarcoidosis is a rare manifestation of systemic sarcoidosis in which firm asymptomaticto-tender subcutaneous nodules develop secondary to sarcoidal granulomas involving the panniculus. Sarcoidosis implies systemic disease, but subcutaneous lesions may present with absent or mild systemic involvement. Here we report 3 cases of isolated subcutaneous nodules with sarcoida...

Systemic lupus erythematosus (SLE) is less likely to present as fever of undetermined origin today. This is due to the widespread use of immunologic tests which permit early diagnosis. It is not surprising therefore that only atypical cases of SLE present as FUa. Although uncommon, pseudotumor cerebri has been recognized as either a presenting manifestation or a complication of SLE. This c...

Pseudotumor cerebri as a presenting manifestation of neurosarcoidosis is rare. This case reported herein had pseudotumor cerebri secondary to dural sinus thrombosis as a presenting feature of neurosarcoidosis without known systemic sarcoidosis. Proper systemic steroid therapy resulted in ocular and systemic recovery. Neurosarcoidosis should be considered in the differential diagnosis of pseudot...

Introduction. To report a case of a conjunctival metastasis as the initial manifestation of small cell lung cancer. Methods. Observational case report. Results. A 50-year-old man without known systemic disease developed a conjunctival mass in his right eye. He underwent incisional biopsy of the tumor and systemic evaluation. Histopathologically, the conjunctival mass was a metastatic small cell...

The skin may exhibit the first clinical evidence of a systemic disease and may provide the first clues to a diagnosis in malignancies. Erythroderma is defined as generalized redness and scaling and it is a clinical manifestation of a variety of underlying diseases including, rarely, solid tumors. Breast cancer is associated with a variety of skin paraneoplastic manifestations like acanthosis ni...