BACKGROUND Many ion channels are preferentially located in caveolae where compartmentalisation/scaffolding with signal transduction components regulates their activity. Channels that are mechanosensitive may be additionally dependent on caveolar control of the mechanical state of the membrane. Here we test which mechanism underlies caveolar-regulation of the mechanosensitive I(Cl,swell) channel...

BACKGROUND/AIMS Articular chondrocytes dwell in an environment that is continuously changing its osmolarity as a consequence of mechanical loading, yet their volume regulation capabilities (RVD) are not fully understood. This work aimed to determine the osmotic sensitivity of freshly isolated rat chondrocytes, their RVD capabilities and to study the properties of any anion currents associated. ...

Rubber profiles fabricated by means of extrusion are widely used in civil engineering, e.g., in pipeline constructions and for window sealings. The dimensioning of injection heads for the extrusion of rubber profiles is exclusively based on empiric knowledge of the non-linear flow behaviour of elastomers, basically of the so-called die swell. The swelling of the extrudate when emerging from a c...

Osmotic cell swelling activates Cl- channels to achieve anion efflux. In this study, we find that both the tyrosine kinase inhibitor herbimycin A and genetic knockout of p56lck, a src-like tyrosine kinase, block regulatory volume decrease (RVD) in a human T cell line. Activation of a swelling-activated chloride current (ICl-swell) by osmotic swelling in whole-cell patch-clamp experiments is blo...

Power quality issues have been a source of major concern in recent years due to extensive use of power electronic devices and non-linear loads in electrical power system. In power systems the common disturbances are voltage sags and swells, usually associated with power system faults. Therefore the effective detection of voltage sags and swells event is an important issue for both voltage sag a...

[1] The anomaly of radar sea spikes, defined here as the non-Bragg scattering events with backscattering cross-section of horizontal polarization exceeding that of the vertical polarization, has been associated with steep wave features possibly going through wavebreaking process, with or without whitecap manifestation. This property is exploited for using a dual polarized radar as a remote sens...

Waves of spontaneous electrical activity and calcium transients occur in the retina during its development. Recent work raises the question of how these waves are produced and propagated.

With the development of critical loads, power quality problem has become particularly important and poor power quality will be cause many adverse effects and the cost of many deaths will follow. To improve power quality and protection of sensitive loads against grid disturbances have been used new equipment based on power electronics similar FACTs devices, they are Custom Power. One of the most...

Neither the effects of repetitive swells on metal-oxide varistors, nor the natural occurrence of swells had been documented in the literature. The paper briefly described a laboratory system capable of generating arbitrary swells and applying them to test varistors. A statistical experiment on five lots of varistors was performed and preliminary results reported. Effects of amplitude, duration,...