The concentration of heavy metals in the environment is normally low. We here address whether using the development of isolated pond snail Radix auricularia eggs would provide a more sensitive endpoint and whether the gelatinous matrix of the egg mass surrounding the eggs indeed protects the snail embryos. In the present study, artificial removal of the gelatinous matrix of egg masses greatly i...

Proanthocyanidins, extracted from grape seeds, are widely used mainly as nutritional supplements. However, there has not been a systematic report to investigate toxicological studies on proanthocyanidins, especially in oral administration. In our studies, proanthocyanidin-rich extract from grape seeds was subjected to a series of toxicological tests to document its safety for use in various foo...

The species Asteraceae Centaurea repens (Asteraceae), known as Acroptilon repens, andTalkhe in persian is used in folk medicine as an emetic, anti-epileptic, and anti-malaria herbin many parts of the world but its toxic effects have not determined yet. This study aimed toevaluate the acute and subchronic toxicity of this extract to find its possible adverse healtheffects through clinical, hemat...

The species Asteraceae Centaurea repens (Asteraceae), known as Acroptilon repens, andTalkhe in persian is used in folk medicine as an emetic, anti-epileptic, and anti-malaria herbin many parts of the world but its toxic effects have not determined yet. This study aimed toevaluate the acute and subchronic toxicity of this extract to find its possible adverse healtheffects through clinical, hemat...

OBJECTIVE Ficus deltoidea leaves have been used in traditional medicine in Southeast Asia to treat diabetes, inflammation, diarrhea, and infections. The present study was conducted to assess the genotoxicity and acute and subchronic toxicity of a standardized methanol extract of F. deltoidea leaves. METHODS Sprague Dawley rats were orally treated with five different single doses of the extrac...

Cyclopentyl methyl ether (CPME) has been used in chemical synthesis as an alternative to hazardous solvents. According to some earlier investigation by others, CPME has low acute or subchronic toxicity with moderate irritation and negative mutagenicity and negative skin sensitization (Local Lymph Node Assay). Calculated Permitted Daily Exposure (PDE) value of CPME obtained by our 28-day oral to...