Purpose: The cancer/testis antigen XAGE1 (GAGED2a) is expressed in approximately 40% of advanced lung adenocarcinomas.We investigated the clinical relevance of the XAGE1 (GAGED2a) immune responses in patients with advanced lung adenocarcinoma. ExperimentalDesign: TheXAGE1 (GAGED2a) antigen expression andEGFRmutationwere determined with tumor tissues. The XAGE1 (GAGED2a) antibody and T-cell immu...

Purpose: Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors andmucin. Thus, we sought to analyze the effect of antibiotics on bacterial density and b-catenin expression within pseudomyxoma peritonei samples. Experim...

This study presents a pharmacokinetic-pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed-sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non-hierarchical (NON-H) and a semi-hierarchical (SEMI-H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of respo...

Decision makers are often unable to choose between the options that they are offered. In these settings they typically defer their decision, that is, delay the decision to a later point in time or avoid the decision altogether. In this paper, we outline eight behavioral findings regarding the causes and consequences of choice deferral that cognitive theories of decision making should be able to...

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In the above paper,1 an asymptotically tight upper bound on the th moment ( 0) of the minimal number of guesses required to determine the value of a random variable was derived. We show that we can tighten this bound for the case of positive integer moments (when = 1, the bound is improved by a factor of 2) and that the new bound also applies to a class of nonminimal guessing sequences.

In this paper we present the results of a method for decoding start codes and overhead information in an MPEG-4 bitstream using sequential decoding with soft channel values. We show that performance of sequential decoding is superior to that of hard decisions alone and can be further improved if probabilities of occurrence of the start codes are taken into consideration.

In this paper, a new notion of sequential compactness is introduced in L-topological spaces, which is called sequentially S∗-compactness. If L = [0, 1], sequential ultra-compactness, sequential N-compactness and sequential strong compactness imply sequential S∗-compactness, and sequential S∗-compactness implies sequential F-compactness. The intersection of a sequentially S∗-compact L-set and a ...