Poorly water soluble molecules are typically formulated for improving their dissolution rate and storage stability by increasing active drug surface area that come in the contact with the dissolution medium [4]. Most important characteristics of nanosuspensions are their exhibited particle size; polydispersity index, drug saturation solubility, physical stability, dissolution rate and bioavaila...

BW 12C, a substituted benzaldehyde, stabilises haemoglobin in the oxy-conformation and has attracted interest as an anti-sickling agent. The drug causes a left shift in the oxygen saturation curve and may induce tumour anoxia and enhance the effect of cytotoxic drugs. During clinical trials in patients with cancer abnormal bands on haemoglobin electrophoretic strips were observed. This made cor...

    The solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. The accumulative s...

    The solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. The accumulative s...

A microscopic mass balance approach has shown that the initial saturation (Is), absorption number (An), dose number (Do), and dissolution number (Dn) are four fundamental dimensionless parameters that can be used to estimate the fraction dose absorbed (~ of suspensions of poorly soluble drugs in humans. The dissolution number of a drug increases with decreasing its particle size. The effect of ...

Purpose: Hydrotropes increases the solubility of organics in water. Objective of present investigation was to enhance the solubility of griseofulvin using the technique of hydrotropic solubilization technique and convert them into suitable oral liquid dosage form (suspension) useful for enhancement of bioavailability. Methods: 0.5M, 1M, 2M of the hydrotropes (tri sodium citrate, urea, sodium ac...

Loratadine, a Class II drug is a second generation antihistaminic agent, which is poorly water soluble with low bioavailability. Loratadine is practically insoluble in water and as such it exhibits poor variable oral bioavailability. Loratadine needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In the present investigation, studies...

The core – mantle differentiation in the magma ocean constitutes a major planetary event that involved two elements are essential to life: carbon (C) and hydrogen (H). These conventionally classified as volatiles (i.e. atmophile), but they can also evolve into being siderophile lithophile at extreme conditions found oceans. We report here model for H C species dissolved silicate melts equilibri...

The study of chemical composition of waters in the abandoned open pyrite mine at WieSciszowice (the Rudawy Janowickie Mts., the W Sudetes, SW Poland) has been canied out with the aim of detennining the conditions of mobi1i7..ation and solubility of aluminium. Both the ion activities and the saturation of water samples with respect to mineral phases have been calculated using the WATEQ4F compute...

Multicomponent crystallization is a method that can modify the physicochemical properties of Carvedilol (CVD), thereby increasing its solubility. Based on in silico screening coformers (Benzoic Acid, Isonicotinamide, and Saccharin) showed non-covalent interactions with CVD, so multicomponent crystal preparation CVD by solvent evaporation used these mole ratios 1:1, 1:2, 2:1. CVD:Isonicotinamide...