Novel glycosidic compounds, 4,6-dialkoxy-1,3,5-triazin-2-yl β-lactosides (DAT-β-Lac), have been prepared directly in water from lactose. The reaction was carried out on a laboratory scale without protecting the hydroxy groups of lactose. The resulting triazine derivatives were found to be recognized by endo-β1,4-glucanase III from Trichoderma reesei (EGIII). The EGIII-catalysed transglycosylati...

a quantitative structure-activity relationship (qsar) study was conducted for the prediction of inhibitory activity of 1-phenyl[2h]-tetrahydro-triazine-3-one analogues as inhibitors of 5-lipoxygenase. the inhibitory activities of the 1-phenyl[2h]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (mlr) ...

A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but gave the corresponding N-triazinyl amino acid derivatives as a major product. The oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) uronium salt was ...

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-...

A number of interesting heterocycles were prepared through interaction of the intermediate 3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno-[2,3-d]pyrimidine (1) and reagents such as hydrazonyl halides 2 to furnish triazine derivatives 4a-l. Reaction of 1 with phenacyl bromide afforded compound 5. Moreover, the title compound 1 was subjected to condensation with active methyl...

A traceless solid-phase synthesis of 6-amino- and 6-hydroxyimino-1,3,5-triazine-2,4-diones and 1,3,5-triazine-2,4,6-triones has been developed. The strategy comprises of linking a preformed N-carbamothioylcarbamate to bromomethyl resin to give a S-linked isothiourea, which then undergoes cyclization with isocynates to yield the resin-bound 1,3,5-triazine-2,4-diones. Subsequent cleavage was acco...

This work includes synthesis a series of some new derivatives triazine from reaction between the sulfur amino acid (L-cysteine) and different aldehydes in dry ethanol to obtain thiazolidine ring as diastereo isomers (Cis Trans)- 2- alkylthiazolidine-4- carboxylic acids (1).
 The (1) suffered esterfication presence drops concentrated sulfuric catalyst give esters :
 ethyl alkylthiazoli...

Equine protozoal myeloencephalitis (EPM) is a nervous system disease caused by the protozoan Sarcocystis neurona. The clinical syndrome caused by the disease can have a variety of presentations. Classically, horses present with asymmetric ataxia and weakness defined by multifocal central nervous system lesions. Successful management of this disease has been frustrated by failure of treatment su...